KABLOLAR - CABLES1

KABLOLAR
Identifikatorlar
Taxalluslar	KABLOLAR, CABL1, CABLES, HsT2563, IK3-1, Cdk5 va Abl fermentlari substrat 1
Tashqi identifikatorlar	OMIM: 609194 MGI: 1927065 HomoloGene: 11097 Generkartalar: KABLOLAR
Gen joylashuvi (odam)
Chr.	Xromosoma 18 (odam)
Oxiri	23,260,467 bp
Gen joylashuvi (Sichqoncha)
Chr.	Xromosoma 18 (sichqoncha)
Oxiri	11,945,630 bp
Gen ontologiyasi
Molekulyar funktsiya	• GO: 0001948 oqsil bilan bog'lanish;
Uyali komponent	• sitoplazma; • sitozol; • hujayra yadrosi;
Biologik jarayon	• hujayra aylanishi; • hujayra aylanishini tartibga solish; • hujayraning bo'linishi; • asab tizimining rivojlanishi;
	Manbalar:Amigo / QuickGO
Ortologlar
	91768
	63955
	ENSG00000134508
	ENSMUSG00000040957
	Q8TDN4
	Q9ESJ1
	NM_001100619; NM_001256438; NM_138375
	NM_001146287; NM_022021
	NP_001094089; NP_001243367; NP_612384
	NP_001139759; NP_071304
	Vikidata
Insonni ko'rish / tahrirlash	Sichqonchani ko'rish / tahrirlash

CDK5 va ABL1 fermentlari substrat 1 a oqsil odamlarda kodlanganligi KABLOLAR gen.^[5]^[6]

CABLES1 - bu a siklinga bog'liq kinaz (CDK) ko'payishida rol o'ynaydigan va / yoki bog'lovchi protein hujayralarni differentsiatsiyasi (Zukerberg va boshq., 2004). [OMIM tomonidan taqdim etilgan].^[6] Bu o'smani bostiruvchi gen uni yo'qotish (mutatsiyalar, nokaut, nokdaun yoki inaktivatsiya bilan) olib kelishi mumkin kolorektal saraton CRC.

Adabiyotlar

^ ^a ^b ^v GRCh38: Ensembl relizi 89: ENSG00000134508 - Ansambl, 2017 yil may
^ ^a ^b ^v GRCm38: Ensembl relizi 89: ENSMUSG00000040957 - Ansambl, 2017 yil may
^ "Human PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.
^ "Sichqoncha PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Mur T , Maks SI, Vang J, Xsi F, Diatchenko L, Marusina K, Fermer AA, Rubin GM, Xong L, Stapleton M, Soares MB, Bonaldo MF, Kasavant TL, Scheetz TE, Braunshteyn MJ, Usdin TB, Toshiyuki S, Karninchi. P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullaxi SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia Garcia, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanches A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG , Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (dekabr 2002). "15000 dan ortiq to'liq uzunlikdagi odam va sichqonchani cDNA sekanslarini yaratish va dastlabki tahlil qilish". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073 / pnas.242603899. PMC 139241. PMID 12477932.
^ ^a ^b "Entrez Gen: CABLES1 Cdk5 va Abl ferment substrat 1".

Tashqi havolalar

Inson KABLOLAR genom joylashuvi va KABLOLAR gen tafsilotlari sahifasida UCSC Genome brauzeri.

Qo'shimcha o'qish

Matsuoka M, Matsuura Y, Semba K, Nishimoto I (2000). "In vivo jonli ravishda siklinga bog'liq kinaz 3 (cdk 3) bilan bog'liq bo'lgan siklinga o'xshash oqsilni molekulyar klonlash". Biokimyo. Biofiz. Res. Kommunal. 273 (2): 442–7. doi:10.1006 / bbrc.2000.2965. PMID 10873625.
Zukerberg LR, Patrik GN, Nikolic M va boshq. (2000). "Kabellar Cdk5 va c-Ablni bog'laydi va Cdk5 tirozin fosforillanishini, kinaz regulyatsiyasini va neyritning o'sishini osonlashtiradi" (PDF). Neyron. 26 (3): 633–46. doi:10.1016 / S0896-6273 (00) 81200-3. hdl:1721.1/83489. PMID 10896159. S2CID 15142577.
Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1 / Kabellar Trap va Pctaire2 bilan bog'langan". Biokimyo. Biofiz. Res. Kommunal. 286 (5): 1045–50. doi:10.1006 / bbrc.2001.5493. PMID 11527406.
Wu CL, Kirley SD, Xiao H va boshq. (2001). "Kabellar Wee1 tomonidan cdk2 tirozin 15 fosforillanishini kuchaytiradi, hujayralar o'sishini inhibe qiladi va ko'plab odam yo'g'on ichak va skuamoz saraton kasalligida yo'qoladi". Saraton kasalligi. 61 (19): 7325–32. PMID 11585773.
Tsuji K, Mizumoto K, Yamochi T va boshq. (2002). "Ik3-1 / kabellarning p53 va p73 ta'sirida hujayralar o'limiga differentsial ta'siri". J. Biol. Kimyoviy. 277 (4): 2951–7. doi:10.1074 / jbc.M108535200. PMID 11706030.
Yamochi T, Semba K, Tsuji K va boshqalar. (2002). "ik3-1 / Kabellar - bu siklinga bog'liq kinaz 3 (cdk 3) uchun substrat". Yevro. J. Biokimyo. 268 (23): 6076–82. doi:10.1046 / j.0014-2956.2001.02555.x. PMID 11733001.
Sato H, Nishimoto I, Matsuoka M (2002). "ik3-1, ik3-1 / kabellariga nisbatan, cdk3, cdk5 va c-abl bilan bog'langan". Biokimyo. Biofiz. Acta. 1574 (2): 157–63. doi:10.1016 / S0167-4781 (01) 00367-0. PMID 11955625.
Tan D, Kirley S, Li Q va boshq. (2003). "Insonning kichik hujayrali bo'lmagan o'pka saratonida kabellar oqsillarini yo'qotilishi: to'qima mikroarray tadqiqotlari". Hum. Pathol. 34 (2): 143–9. doi:10.1053 / hupa.2003.26. PMID 12612882.
Dong Q, Kirley S, Rueda B va boshq. (2004). "Kabellarning yo'qolishi, 18q xromosomadagi yangi gen, tuxumdon saratonida". Tartibni Pathol. 16 (9): 863–8. doi:10.1097 / 01.MP.0000084434.88269.0A. PMID 13679449.
Matsuoka M, Sudo H, Tsuji K va boshq. (2004). "ik3-2, ik3-1 / Kabellarga nisbatan, ikkala p53 vositachiligida va p53 mustaqil apoptotik yo'llarda qatnashadi". Biokimyo. Biofiz. Res. Kommunal. 312 (2): 520–9. doi:10.1016 / j.bbrc.2003.10.142. PMID 14637168.
Ota T, Suzuki Y, Nishikava T va boshq. (2004). "21,243 to'liq uzunlikdagi odam cDNA-larining to'liq ketma-ketligi va tavsifi". Nat. Genet. 36 (1): 40–5. doi:10.1038 / ng1285. PMID 14702039.
Zukerberg LR, DeBernardo RL, Kirley SD va boshq. (2004). "Kabellarning yo'qolishi, siklinga bog'liq kinaz regulyatsion oqsil, endometriyal giperplaziya va endometriyal saraton rivojlanishi bilan bog'liq". Saraton kasalligi. 64 (1): 202–8. doi:10.1158 / 0008-5472. CAN-03-2833. PMID 14729625.
Gerxard DS, Vagner L, Feingold EA va boshq. (2004). "NIH to'liq metrajli cDNA loyihasining holati, sifati va kengayishi: sutemizuvchilar genlari to'plami (MGC)". Genom Res. 14 (10B): 2121-7. doi:10.1101 / gr.2596504. PMC 528928. PMID 15489334.
Zhang H, Duan HO, Kirley SD va boshqalar. (2006). "Odam saratonida CDK regulyatori bo'lgan kabellar genining abberrant qo'shilishi". Saraton biol. Ther. 4 (11): 1211–5. doi:10.4161 / cbt.4.11.2085. PMID 16177568.
Nusbaum C, Zody MC, Borowsky ML va boshq. (2005). "DNKning ketma-ketligi va odam xromosomasining tahlili 18". Tabiat. 437 (7058): 551–5. doi:10.1038 / nature03983. PMID 16177791.
Beausoleil SA, Villén J, Gerber SA va boshqalar. (2006). "Yuqori oqsilli fosforillanish tahlili va joyni lokalizatsiya qilish uchun ehtimollikka asoslangan yondashuv". Nat. Biotexnol. 24 (10): 1285–92. doi:10.1038 / nbt1240. PMID 16964243. S2CID 14294292.
Xirao N, Sato S, Gotoh T va boshq. (2007). "NESH (Abi-3) Abi / WAVE kompleksida mavjud, ammo c-Abl vositachiligidagi fosforillanishni rivojlantirmaydi". FEBS Lett. 580 (27): 6464–70. doi:10.1016 / j.febslet.2006.10.065. PMID 17101133. S2CID 20005197.

Ushbu maqola gen kuni inson xromosomasi 18 a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[refGRCh38Ensembl-1] v GRCh38: Ensembl relizi 89: ENSG00000134508 - Ansambl, 2017 yil may

[refGRCm38Ensembl-2] v GRCm38: Ensembl relizi 89: ENSMUSG00000040957 - Ansambl, 2017 yil may

[3] "Human PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.

[4] "Sichqoncha PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Mur T , Maks SI, Vang J, Xsi F, Diatchenko L, Marusina K, Fermer AA, Rubin GM, Xong L, Stapleton M, Soares MB, Bonaldo MF, Kasavant TL, Scheetz TE, Braunshteyn MJ, Usdin TB, Toshiyuki S, Karninchi. P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullaxi SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia Garcia, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanches A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG , Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (dekabr 2002). "15000 dan ortiq to'liq uzunlikdagi odam va sichqonchani cDNA sekanslarini yaratish va dastlabki tahlil qilish". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073 / pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gen: CABLES1 Cdk5 va Abl ferment substrat 1".

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