SF3B14 - SF3B14

SF3B6
Mavjud tuzilmalar
PDB	Ortholog qidiruvi: PDBe RCSB
PDB id kodlari ro'yxati
	2F9D, 2F9J, 2FHO, 3LQV
Identifikatorlar
Taxalluslar	SF3B6, HSPC175, Ht006, P14, SAP14, SAP14a, SF3B14, SF3B14a, CGI-110, biriktiruvchi omil 3b kichik birlik 6
Tashqi identifikatorlar	OMIM: 607835 MGI: 1913305 HomoloGene: 9360 Generkartalar: SF3B6
Gen joylashuvi (odam)
Chr.	Xromosoma 2 (odam)
Oxiri	24,076,373 bp
Gen joylashuvi (Sichqoncha)
Chr.	Xromosoma 12 (sichqoncha)
Oxiri	4,827,659 bp
Gen ontologiyasi
Molekulyar funktsiya	• nuklein kislota bilan bog'lanish; • RNK bilan bog'lanish; • GO: 0001948 oqsil bilan bog'lanish; • mRNA bilan bog'lanish;
Uyali komponent	• katalitik 2-bosqich splitseozoma; • U12 tipli splitseozomal kompleks; • U2 tipli splitseozomal kompleks; • prekatalitik splitseozoma; • hujayra yadrosi; • U2 snRNP; • nukleoplazma; • splitseozoma kompleksi;
Biologik jarayon	• mRNK qo'shilishi, splitseozoma orqali; • mRNKni qayta ishlash; • blastokist shakllanishi; • RNK qo'shilishi;
	Manbalar:Amigo / QuickGO
Ortologlar
	51639
	66055
	ENSG00000115128
	ENSMUSG00000037361
	Q9Y3B4
	P59708
	NM_016047
	NM_025323
	NP_057131
	NP_079599
	Vikidata
Insonni ko'rish / tahrirlash	Sichqonchani ko'rish / tahrirlash

Birlashtirish omili 3B, 14 kDa subbirlik, shuningdek, nomi bilan tanilgan SF3B14, inson gen.^[5]

Funktsiya

Ushbu gen 3b biriktiruvchi omil kompleksining 14 kDa oqsil subbirligini kodlaydi. Splitsing faktor 3b splicosomalarning U2 va U11 / U12 kichik yadroli ribonukleoprotein komplekslari (U2 snRNP) bilan bog'lanadi. Ushbu 14 kDa oqsil 3b biriktiruvchi omil kompleksining 1-bo'linmasi bilan bevosita ta'sir o'tkazadi. Ushbu 14 kDa oqsili, shuningdek, mRNKdan oldingi filial joyida qo'shilishning birinchi transesterifikatsiya bosqichini amalga oshiradigan adenozin bilan bevosita ta'sir o'tkazadi.^[5]

O'zaro aloqalar

SF3B14 ga ko'rsatildi o'zaro ta'sir qilish bilan SF3B1.^[6]^[7]

Adabiyotlar

^ ^a ^b ^v GRCh38: Ensembl relizi 89: ENSG00000115128 - Ansambl, 2017 yil may
^ ^a ^b ^v GRCm38: Ensembl relizi 89: ENSMUSG00000037361 - Ansambl, 2017 yil may
^ "Human PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.
^ "Sichqoncha PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.
^ ^a ^b "Entrez Gen: SF3B14 biriktiruvchi omil 3B, 14 kDa subbirlik".
^ Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC (2001 yil avgust). "UR va U11 / U12 snRNP oqsili mRNKdan oldingi filial joyi bilan bog'langan". EMBO J. 20 (16): 4536–46. doi:10.1093 / emboj / 20.16.4536. PMC 125580. PMID 11500380.
^ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (sentyabr 2002). "Yangi SF3b va 17S U2 snRNP oqsillarining xarakteristikasi, shu jumladan inson Prp5p gomologi va SF3b DEAD-box oqsillari". EMBO J. 21 (18): 4978–88. doi:10.1093 / emboj / cdf480. PMC 126279. PMID 12234937.

Qo'shimcha o'qish

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Zhang QH, Ye M, Vu XY, Ren SX, Chjao M, Chjao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Xan ZG, Zhang JW, Tao J, Xuan QH, Chjou J , Xu GX, Gu J, Chen SJ, Chen Z (2000). "CD34 + gematopoetik ildiz / nasl qoldiruvchi hujayralarda ifodalangan oldindan aniqlanmagan 300 gen uchun ochiq o'qish ramkalari bilan kDNKlarni klonlash va funktsional tahlil qilish". Genom Res. 10 (10): 1546–60. doi:10.1101 / gr.140200. PMC 310934. PMID 11042152.
Xarrington JJ, Sherf B, Rundlett S, Jekson PD, Perri R, Keyn S, Leventhal C, Tornton M, Ramachandran R, Uittington J, Lerner L, Kostanzo D, Makeleligot K, Boozer S, Mey R, Smit E, Veloso N , Klika A, Xess J, Kotren K, Lo K, Offenbaxer J, Danzig J, Dyukar M (2001). "Gen ekspressionining tasodifiy faollashuvidan foydalangan holda genom bo'yicha oqsil ekspression kutubxonalarini yaratish". Nat. Biotexnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC (2001). "UR va U11 / U12 snRNP oqsili mRNKdan oldingi filial joyi bilan bog'langan". EMBO J. 20 (16): 4536–46. doi:10.1093 / emboj / 20.16.4536. PMC 125580. PMID 11500380.
Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (2002). "Yangi SF3b va 17S U2 snRNP oqsillarining xarakteristikasi, shu jumladan inson Prp5p gomologi va SF3b DEAD-box oqsillari". EMBO J. 21 (18): 4978–88. doi:10.1093 / emboj / cdf480. PMC 126279. PMID 12234937.
Golas MM, Sander B, Will CL, Lyurmann R, Stark H (2003). "Ko'p proteinli biriktiruvchi omil SF3b ning molekulyar arxitekturasi". Ilm-fan. 300 (5621): 980–4. doi:10.1126 / science.1084155. PMID 12738865. S2CID 31046270.
Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R (2004). "Inson 18S U11 / U12 snRNP tarkibida U2 ga bog'liq splitsozomada mavjud bo'lmagan yangi oqsillar to'plami mavjud". RNK. 10 (6): 929–41. doi:10.1261 / rna.7320604. PMC 1370585. PMID 15146077.
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Ushbu maqola gen kuni inson xromosomasi 2 a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[refGRCh38Ensembl-1] v GRCh38: Ensembl relizi 89: ENSG00000115128 - Ansambl, 2017 yil may

[refGRCm38Ensembl-2] v GRCm38: Ensembl relizi 89: ENSMUSG00000037361 - Ansambl, 2017 yil may

[3] "Human PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.

[4] "Sichqoncha PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.

[entrez-5] "Entrez Gen: SF3B14 biriktiruvchi omil 3B, 14 kDa subbirlik".

[pmid11500380-6] Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC (2001 yil avgust). "UR va U11 / U12 snRNP oqsili mRNKdan oldingi filial joyi bilan bog'langan". EMBO J. 20 (16): 4536–46. doi:10.1093 / emboj / 20.16.4536. PMC 125580. PMID 11500380.

[pmid12234937-7] Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (sentyabr 2002). "Yangi SF3b va 17S U2 snRNP oqsillarining xarakteristikasi, shu jumladan inson Prp5p gomologi va SF3b DEAD-box oqsillari". EMBO J. 21 (18): 4978–88. doi:10.1093 / emboj / cdf480. PMC 126279. PMID 12234937.

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