SRPK2 - SRPK2

SRPK2
Mavjud tuzilmalar
PDB	Ortholog qidiruvi: PDBe RCSB
PDB id kodlari ro'yxati
	2X7G
Identifikatorlar
Taxalluslar	SRPK2, SFRSK2, SRSF oqsil kinaz 2
Tashqi identifikatorlar	OMIM: 602980 MGI: 1201408 HomoloGene: 101663 Generkartalar: SRPK2
Gen joylashuvi (odam)
Chr.	Xromosoma 7 (odam)
Oxiri	105,399,308 bp
Gen joylashuvi (Sichqoncha)
Chr.	Xromosoma 5 (sichqoncha)
Oxiri	23,684,617 bp
RNK ekspressioni naqsh
	; ; ; ;
	Qo'shimcha ma'lumotni ifodalash ma'lumotlari
Gen ontologiyasi
Molekulyar funktsiya	• transferaza faoliyati; • nukleotid bilan bog'lanish; • protein kinaz faolligi; • 14-3-3 protein bilan bog'lanish; • kinaz faolligi; • oqsil serin / treonin kinaz faolligi; • GO: 0001948 oqsil bilan bog'lanish; • ATP majburiy; • magnezium ionlari bilan bog'lanish; • RNK bilan bog'lanish;
Uyali komponent	• sitoplazma; • nukleoplazma; • nukleus; • hujayra yadrosi; • sitozol;
Biologik jarayon	• hujayralarni differentsiatsiyasi; • GO: 0007243 hujayra ichidagi signal uzatilishi; • yadroviy dog 'tashkiloti; • fosforillanish; • mRNKni qayta ishlash; • mRNK qo'shilishini regulyatsiya qilish, splitseozoma orqali; • oqsil fosforillanishi; • splitseozomal kompleks yig'ish; • neyron apoptotik jarayonini ijobiy tartibga solish; • virusli genom replikatsiyasining salbiy regulyatsiyasi; • gen ekspressionining ijobiy regulyatsiyasi; • hujayra aylanishining ijobiy regulyatsiyasi; • angiogenez; • RNK qo'shilishi; • hujayralar ko'payishini ijobiy tartibga solish; • virusli genom replikatsiyasining ijobiy regulyatsiyasi; • tug'ma immunitet tizimi; • gen ekspressionini tartibga solish; • mRNKni qayta ishlashni tartibga solish;
	Manbalar:Amigo / QuickGO
Ortologlar
	6733
	20817
	ENSG00000135250
	ENSMUSG00000062604
	P78362
	O54781
NM_001278273; NM_182691; NM_182692; NM_001350738; NM_001350739;
	NM_001350740; NM_001350741; NM_001350742; NM_001350743; NM_001350744; NM_001350745; NM_001350746
NM_009274; NM_001359172; NM_001359173; NM_001359174; NM_001359175;
	NM_001359176
NP_001265202; NP_872633; NP_872634; NP_001337667; NP_001337668;
	NP_001337669; NP_001337670; NP_001337671; NP_001337672; NP_001337673; NP_001337674; NP_001337675
NP_033300; NP_001346101; NP_001346102; NP_001346103; NP_001346104;
	NP_001346105
	Vikidata
Insonni ko'rish / tahrirlash	Sichqonchani ko'rish / tahrirlash

Serin / treonin-protein kinaz SRPK2 bu ferment odamlarda kodlanganligi SRPK2 gen.^[5]^[6]^[7]

O'zaro aloqalar

SRPK2 ko'rsatildi o'zaro ta'sir qilish bilan:

ASF / SF2^[6]^[8]^[9] va
U2AF2.^[6]^[10]

Adabiyotlar

^ ^a ^b ^v GRCh38: Ensembl relizi 89: ENSG00000135250 - Ansambl, 2017 yil may
^ ^a ^b ^v GRCm38: Ensembl relizi 89: ENSMUSG00000062604 - Ansambl, 2017 yil may
^ "Human PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.
^ "Sichqoncha PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.
^ Gui JF, Lane WS, Fu XD (Iyul 1994). "Serin kinaz hujayra tsiklida biriktiruvchi omillarning hujayra ichidagi lokalizatsiyasini tartibga soladi". Tabiat. 369 (6482): 678–82. doi:10.1038 / 369678a0. PMID 8208298. S2CID 4275539.
^ ^a ^b ^v Vang HY, Lin V, Dyuk JA, Yeakli JM, Songyang Z, Kantli LC, Fu XD (Mar, 1998). "SRPK2: sutemizuvchi hujayralardagi mRNK qo'shilish omillarining o'zaro ta'siri va lokalizatsiyasida vositachilikda ishtirok etadigan SR oqsiliga xos kinazning differentsial ifodalanganligi". J hujayra biol. 140 (4): 737–50. doi:10.1083 / jcb.140.4.737. PMC 2141757. PMID 9472028.
^ "Entrez Gen: SRPK2 SFRS protein kinaz 2".
^ Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Fevral 2003). "Sisplatin bilan davolashning serin / arginga boy bo'lgan CROP / Luc7A yadroviy oqsilining dog'li tarqalishiga ta'siri". Biokimyo. Biofiz. Res. Kommunal. 301 (2): 324–9. doi:10.1016 / s0006-291x (02) 03017-6. PMID 12565863.
^ Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (1999 yil aprel). "SF2 / ASF ning hujayra osti lokalizatsiyasi SR oqsil kinazlari (SRPK) bilan bevosita ta'sir o'tkazish orqali tartibga solinadi". J. Biol. Kimyoviy. 274 (16): 11125–31. doi:10.1074 / jbc.274.16.11125. PMID 10196197.
^ Rual JF, Venkatesan K, Xao T, Xirozane-Kishikava T, Drikot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Gedehoussou N, Klitgord N, Saymon S, Boxem M, Milshteyn S, Rozenberg J, Goldberg DS, Zhang LV, Vong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Ducette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (oktyabr 2005). "Odamning oqsil va oqsil bilan o'zaro aloqasi tarmog'ining proteom miqyosli xaritasi tomon". Tabiat. 437 (7062): 1173–8. doi:10.1038 / nature04209. PMID 16189514. S2CID 4427026.

Qo'shimcha o'qish

Bedford MT, Chan DC, Leder P (1997). "FBP WW domenlari va Abl SH3 domeni prolinlarga boy ligandlarning ma'lum bir sinfiga bog'lanadi". EMBO J. 16 (9): 2376–83. doi:10.1093 / emboj / 16.9.2376. PMC 1169838. PMID 9171351.
Kuroyanagi N, Onogi H, Vakabayashi T, Xagivara M (1998). "SR-oqsilga xos kinaz, SRPK2, yadro dog'larini demontaj qiladi". Biokimyo. Biofiz. Res. Kommunal. 242 (2): 357–64. doi:10.1006 / bbrc.1997.7913. PMID 9446799.
Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (1999). "SF2 / ASF ning hujayra osti lokalizatsiyasi SR oqsil kinazlari (SRPK) bilan bevosita ta'sir o'tkazish orqali tartibga solinadi". J. Biol. Kimyoviy. 274 (16): 11125–31. doi:10.1074 / jbc.274.16.11125. PMID 10196197.
Daub H, Blencke S, Xabenberger P, Kurtenbax A, Dennenmoser J, Vissing J, Ullrix A, Kotten M (2002). "SRPK1 va SRPK2 ni asosiy hujayrali oqsil kinazalari sifatida gepatit B virusi yadrosi oqsilini fosforlashtiradigan narsa". J. Virol. 76 (16): 8124–37. doi:10.1128 / JVI.76.16.8124-8137.2002. PMC 155132. PMID 12134018.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Immobilizatsiyalangan metallga o'xshashlik xromatografiyasi va tandem mass-spektrometriyasi yordamida odamning T hujayralaridan tirozin fosforillanish joylarini mustahkam fosfoproteomik profillash". Anal. Kimyoviy. 76 (10): 2763–72. doi:10.1021 / ac035352d. PMID 15144186.
Rush J, Moritz A, Li KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Saraton hujayralarida tirozin fosforillanishining immunoafinity profilaktikasi". Nat. Biotexnol. 23 (1): 94–101. doi:10.1038 / nbt1046. PMID 15592455. S2CID 7200157.
Zheng Y, Fu XD, Ou JH (2005). "Gepatit B virusi replikatsiyasini SRPK1 va SRPK2 tomonidan virusli yadro oqsilining fosforlanishidan mustaqil yo'l orqali bostirish". Virusologiya. 342 (1): 150–8. doi:10.1016 / j.virol.2005.07.030. PMID 16122776.
Rual JF, Venkatesan K, Xao T, Xirozane-Kishikava T, Drikot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Gedehoussou N, Klitgord N, Saymon C, Boxem M, Milshteyn S, Rozenberg J, Goldberg DS, Zhang LV, Vong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill Hill, Roth FP, Vidal M (2005). "Odamning oqsil va oqsil bilan o'zaro aloqasi tarmog'ining proteom miqyosli xaritasi tomon". Tabiat. 437 (7062): 1173–8. doi:10.1038 / nature04209. PMID 16189514. S2CID 4427026.

Ushbu maqola gen kuni inson xromosomasi 7 a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[refGRCh38Ensembl-1] v GRCh38: Ensembl relizi 89: ENSG00000135250 - Ansambl, 2017 yil may

[refGRCm38Ensembl-2] v GRCm38: Ensembl relizi 89: ENSMUSG00000062604 - Ansambl, 2017 yil may

[3] "Human PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.

[4] "Sichqoncha PubMed ma'lumotnomasi:". Milliy Biotexnologiya Axborot Markazi, AQSh Milliy Tibbiyot Kutubxonasi.

[pmid8208298-5] Gui JF, Lane WS, Fu XD (Iyul 1994). "Serin kinaz hujayra tsiklida biriktiruvchi omillarning hujayra ichidagi lokalizatsiyasini tartibga soladi". Tabiat. 369 (6482): 678–82. doi:10.1038 / 369678a0. PMID 8208298. S2CID 4275539.

[pmid9472028-6] v Vang HY, Lin V, Dyuk JA, Yeakli JM, Songyang Z, Kantli LC, Fu XD (Mar, 1998). "SRPK2: sutemizuvchi hujayralardagi mRNK qo'shilish omillarining o'zaro ta'siri va lokalizatsiyasida vositachilikda ishtirok etadigan SR oqsiliga xos kinazning differentsial ifodalanganligi". J hujayra biol. 140 (4): 737–50. doi:10.1083 / jcb.140.4.737. PMC 2141757. PMID 9472028.

[entrez-7] "Entrez Gen: SRPK2 SFRS protein kinaz 2".

[pmid12565863-8] Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Fevral 2003). "Sisplatin bilan davolashning serin / arginga boy bo'lgan CROP / Luc7A yadroviy oqsilining dog'li tarqalishiga ta'siri". Biokimyo. Biofiz. Res. Kommunal. 301 (2): 324–9. doi:10.1016 / s0006-291x (02) 03017-6. PMID 12565863.

[pmid10196197-9] Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (1999 yil aprel). "SF2 / ASF ning hujayra osti lokalizatsiyasi SR oqsil kinazlari (SRPK) bilan bevosita ta'sir o'tkazish orqali tartibga solinadi". J. Biol. Kimyoviy. 274 (16): 11125–31. doi:10.1074 / jbc.274.16.11125. PMID 10196197.

[pmid16189514-10] Rual JF, Venkatesan K, Xao T, Xirozane-Kishikava T, Drikot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Gedehoussou N, Klitgord N, Saymon S, Boxem M, Milshteyn S, Rozenberg J, Goldberg DS, Zhang LV, Vong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Ducette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (oktyabr 2005). "Odamning oqsil va oqsil bilan o'zaro aloqasi tarmog'ining proteom miqyosli xaritasi tomon". Tabiat. 437 (7062): 1173–8. doi:10.1038 / nature04209. PMID 16189514. S2CID 4427026.

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