Talopeptin - Talopeptin

Talopeptin
Ismlar
	IUPAC nomi (2S)-2-[[(2S) -2 - [[gidroksi - [(2.)S,3R,4R,5S,6S) -3,4,5-trihidroksi-6-metiloksan-2-yl] oksifosforil] amino] -4-metilpentanoyl] amino] -3- (1H-indol-3-il) propanoik kislota
	Boshqa ismlar N-[N- [[(6-oksidlanish-a-L-talopiranosil) oksi] gidroksifosfinil] -L-leusil] -L-triptofan
Identifikatorlar
CAS raqami	84235-60-9 ;
3D model (JSmol )	Interaktiv rasm;
ChemSpider	118729 ;
PubChem CID	134712;
	InChI InChI = 1S / C23H34N3O10P / c1-11 (2) 8-16 (26-37 (33,34) 36-23-20 (29) 19 (28) 18 (27) 12 (3) 35-23) 21) 30) 25-17 (22 (31) 32) 9-13-10-24-15-7-5-4-6-14 (13) 15 / h4-7,10-12,16-20,23- 24,27-29H, 8-9H2,1-3H3, (H, 25,30) (H, 31,32) (H2,26,33,34) / t12-, 16-, 17-, 18 +, 19 +, 20 +, 23- / m0 / s1 Kalit: ZPHBZEQOLSRPAK-XVOJFHBISA-N ; InChI = 1 / C23H34N3O10P / c1-11 (2) 8-16 (26-37 (33,34) 36-23-20 (29) 19 (28) 18 (27) 12 (3) 35-23) 21) 30) 25-17 (22 (31) 32) 9-13-10-24-15-7-5-4-6-14 (13) 15 / h4-7,10-12,16-20,23- 24,27-29H, 8-9H2,1-3H3, (H, 25,30) (H, 31,32) (H2,26,33,34) / t12-, 16-, 17-, 18 +, 19 +, 20 +, 23- / m0 / s1 Kalit: ZPHBZEQOLSRPAK-XVOJFHBIBA;
	Jilmayganlar O = C (O) [C @@ H] (NC ([C @ H] (CC (C) C) NP (O [C @@ H) 1O [C @@ H] (C) [C @@ ” H] (O) [C @@ H] (O) [C @ H] 1O) (O) = O) = O) CC2 = CNC3 = C2C = CC = C3;
Xususiyatlari
Kimyoviy formulalar	C23H34N3O10P
Molyar massa	543.510 g · mol−1
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	tasdiqlang (nima bu ?)
	Infobox ma'lumotnomalari

Talopeptin madaniyati asosida olingan kimyoviy birikma Streptomitsiyalar. Bu ma'lum bo'lgan qaytariladigan narsadir inhibitor ning termolizin^[1] va boshqasini inhibe qilishi kutilmoqda metalloproteinazlar.^[2]^[3] Kimyoviy jihatdan talopeptin peptidaza inhibitori bilan chambarchas bog'liq fosforamidon bitta stereo markaz orqali.

Adabiyotlar

^ Kitagishi, Keyko; Xiromi, Keitaro (1984). "Talopeptinning inhibitiv spektri (MKI), termolizinning o'ziga xos inhibitori". Qishloq xo'jaligi va biologik kimyo. 48 (5): 1287–91. doi:10.1271 / bbb1961.48.1287.
^ Fukuxara, Kenichi; Murao, Savo; Nozava, Tsunenori; Hatano, Masaxiro (1982). "Talopeptin (MK-I), Streptomyces mozunensis MK-23 tomonidan ishlab chiqarilgan yangi metallo proteinaz inhibitori" ning strukturaviy yoritilishi. Tetraedr xatlari. 23 (22): 2319–22. doi:10.1016 / S0040-4039 (00) 87331-1.
^ Kitagishi, Keyko; Xiromi, Keytaro; Oda, Kohei; Murao, Savo (1983). "Termolizin va Streptomitses metalloproteaza inhibitori, talopeptin (MKI) o'rtasidagi bog'lanish bo'yicha muvozanatni o'rganish". Biokimyo jurnali. 93 (1): 47–53. doi:10.1093 / oxfordjournals.jbchem.a134176. PMID 6341369.

Tashqi havolalar

The MEROPS peptidazalar va ularning inhibitorlari uchun onlayn ma'lumotlar bazasi: Talopeptin

[1] Kitagishi, Keyko; Xiromi, Keitaro (1984). "Talopeptinning inhibitiv spektri (MKI), termolizinning o'ziga xos inhibitori". Qishloq xo'jaligi va biologik kimyo. 48 (5): 1287–91. doi:10.1271 / bbb1961.48.1287.

[2] Fukuxara, Kenichi; Murao, Savo; Nozava, Tsunenori; Hatano, Masaxiro (1982). "Talopeptin (MK-I), Streptomyces mozunensis MK-23 tomonidan ishlab chiqarilgan yangi metallo proteinaz inhibitori" ning strukturaviy yoritilishi. Tetraedr xatlari. 23 (22): 2319–22. doi:10.1016 / S0040-4039 (00) 87331-1.

[3] Kitagishi, Keyko; Xiromi, Keytaro; Oda, Kohei; Murao, Savo (1983). "Termolizin va Streptomitses metalloproteaza inhibitori, talopeptin (MKI) o'rtasidagi bog'lanish bo'yicha muvozanatni o'rganish". Biokimyo jurnali. 93 (1): 47–53. doi:10.1093 / oxfordjournals.jbchem.a134176. PMID 6341369.

[1]

[2]

[3]

Ismlar

IUPAC nomi (2S)-2-[[(2S) -2 - [[gidroksi - [(2.)S,3R,4R,5S,6S) -3,4,5-trihidroksi-6-metiloksan-2-yl] oksifosforil] amino] -4-metilpentanoyl] amino] -3- (1H-indol-3-il) propanoik kislota
Boshqa ismlar N-[N- [[(6-oksidlanish-a-L-talopiranosil) oksi] gidroksifosfinil] -L-leusil] -L-triptofan
Identifikatorlar
CAS raqami	84235-60-9^Y
3D model (JSmol )	Interaktiv rasm
ChemSpider	118729^N
PubChem CID	134712
InChI InChI = 1S / C23H34N3O10P / c1-11 (2) 8-16 (26-37 (33,34) 36-23-20 (29) 19 (28) 18 (27) 12 (3) 35-23) 21) 30) 25-17 (22 (31) 32) 9-13-10-24-15-7-5-4-6-14 (13) 15 / h4-7,10-12,16-20,23- 24,27-29H, 8-9H2,1-3H3, (H, 25,30) (H, 31,32) (H2,26,33,34) / t12-, 16-, 17-, 18 +, 19 +, 20 +, 23- / m0 / s1^N Kalit: ZPHBZEQOLSRPAK-XVOJFHBISA-N^N InChI = 1 / C23H34N3O10P / c1-11 (2) 8-16 (26-37 (33,34) 36-23-20 (29) 19 (28) 18 (27) 12 (3) 35-23) 21) 30) 25-17 (22 (31) 32) 9-13-10-24-15-7-5-4-6-14 (13) 15 / h4-7,10-12,16-20,23- 24,27-29H, 8-9H2,1-3H3, (H, 25,30) (H, 31,32) (H2,26,33,34) / t12-, 16-, 17-, 18 +, 19 +, 20 +, 23- / m0 / s1 Kalit: ZPHBZEQOLSRPAK-XVOJFHBIBA
Jilmayganlar O = C (O) [C @@ H] (NC ([C @ H] (CC (C) C) NP (O [C @@ H) 1O [C @@ H] (C) [C @@ ” H] (O) [C @@ H] (O) [C @ H] 1O) (O) = O) = O) CC2 = CNC3 = C2C = CC = C3
Xususiyatlari
Kimyoviy formulalar	C₂₃H₃₄N₃O₁₀P
Molyar massa	543.510 g · mol⁻¹
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
N tasdiqlang (nima bu ^YN ?)
Infobox ma'lumotnomalari