Tanespimitsin - Tanespimycin - Wikipedia

Tanespimitsin
Ismlar
	IUPAC nomi [(3S,5S,6R,7S,8E,10R,11S,12E,14E) -21- (allilamino) -6-gidroksi-5,11-dimetoksi-3,7,9,15-tetrametil-16,20,22-trioxo-17-azabitsiklo [16.3.1] docosa-8,12, 14,18,21-pentaen-10-yl] karbamat
	Boshqa ismlar 17-N-Allilino-17-demetoksigeldanamitsin; 17-AAG
Identifikatorlar
CAS raqami	75747-14-7 ;
3D model (JSmol )	Interaktiv rasm; Interaktiv rasm;
ChEMBL	ChEMBL109480 ;
ChemSpider	21106220 ;
IUPHAR / BPS	7751;
PubChem CID	6440175;
UNII	4GY0AVT3L4 ;
CompTox boshqaruv paneli (EPA)	DTXSID5046352 ;
	InChI InChI = 1S / C31H43N3O8 / c1-8-12-33-26-21-13-17 (2) 14-25 (41-7) 27 (36) 19 (4) 15-20 (5) 29 (42-) 31 (32) 39) 24 (40-6) 11-9-10-18 (3) 30 (38) 34-22 (28 (21) 37) 16-23 (26) 35 / h8-11,15-) 17,19,24-25,27,29,33,36H, 1,12-14H2,2-7H3, (H2,32,39) (H, 34,38) / b11-9-, 18-10 + , 20-15 + / t17-, 19 +, 24 +, 25 +, 27-, 29 + / m1 / s1 Kalit: AYUNIORJHRXIBJ-TXHRRWQRSA-N ; InChI = 1 / C31H43N3O8 / c1-8-12-33-26-21-13-17 (2) 14-25 (41-7) 27 (36) 19 (4) 15-20 (5) 29 (42-) 31 (32) 39) 24 (40-6) 11-9-10-18 (3) 30 (38) 34-22 (28 (21) 37) 16-23 (26) 35 / h8-11,15-) 17,19,24-25,27,29,33,36H, 1,12-14H2,2-7H3, (H2,32,39) (H, 34,38) / b11-9-, 18-10 + , 20-15 + / t17-, 19 +, 24 +, 25 +, 27-, 29 + / m1 / s1 Kalit: AYUNIORJHRXIBJ-TXHRRWQRBY;
	Jilmayganlar NC (= O) O [C @ H] 1C (/ C) = C / [C @ H] (C) [C @@ H] (O) [C @@ H] (OC) C [C @ H ] (C) C C2 = C (/ NCC = C) C (= O) C = C ( NC (= O) C ( C) = C C = C / [C @@ H] 1OC ) C2 = O; C [C @ H] 1C [C @@ H] ([C @@ H] ([C @ H] (/ C = C (/ [C @@ H) ([C @ H] (/ C = C C = C ( C (= O) NC2 = CC (= O) C (= C (C1) C2 = O) NCC = C) / C) OC) OC (= O) N) C) C) O) OC;
Xususiyatlari
Kimyoviy formulalar	C31H43N3O8
Molyar massa	585.698 g · mol−1
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	tasdiqlang (nima bu ?)
	Infobox ma'lumotnomalari

Tanespimitsin (17-N-alilamino-17-demetoksigeldanamitsin, 17-AAG) antibiotikning hosilasi hisoblanadi geldanamitsin davolashda o'rganilmoqda saraton, aniqrog'i ayrim turdagi yosh bemorlarda leykemiya yoki qattiq o'smalar, ayniqsa buyrak o'smalar.

Bu ishlaydi taqiqlovchi Hsp90, bu o'sha o'smalarda ifodalanadi.^[1]

Bu oilaga tegishli giyohvand moddalar deb nomlangan antitümörlü antibiotiklar.

Klinik sinovlar

Bristol-Mayers Squibb 1-bosqichni o'tkazdi^[2]^[3] va 2-bosqich klinik sinovlar. Biroq, 2010 yilda kompaniya to'xtadi rivojlanish tanespimitsin, ko'p bosqichli miyelomani davolash uchun potentsial davo sifatida kech bosqich klinik tadqiqotlar paytida. Hech qanday aniq tushuntirish berilmagan bo'lsa-da, Bristol-Mayers Skvibb tanespimitsinni ishlab chiqarishning moliyaviy maqsadga muvofiqligi va ushbu birikma bo'yicha patentning 2014 yilgi amal qilish muddati tugaganligi sababli ishlab chiqarishni to'xtatib qo'yganligi va ishlab chiqarishning nisbatan xarajatlari haqida gap ketmoqda.^[4]

Adabiyotlar

^ Dimopulos, MA; Mitsiades, CS; Anderson, KC; Richardson, PG (2011). "Tanespimitsin antitümör davolash sifatida". Klinik lenfoma, miyeloma va leykemiya. 11 (1): 17–22. doi:10.3816 / CLML.2011.n.002. PMID 21454186.
^ http://www.clinicaltrials.gov/ct/show/NCT00093821 1-bosqich sinovi: 17-N-Allylamino-17-Demetoksigeldanamitsin (17-AAG) yosh bemorlarni takroriy yoki refrakter leykemiya yoki qattiq o'smalar bilan davolashda
^ http://www.clinicaltrials.gov/ct/show/NCT00079404 1-bosqich sinovi: 17-N-Allylamino-17-Demetoksigeldanamitsin relapsli yoki refrakter qattiq o'smalar yoki leykemiya bilan kasallangan yosh bemorlarni davolashda.
^ "Bristol-Myers Skvib tanespimitsinni ishlab chiqarishni to'xtatdi".

Tashqi havolalar

[1] Dimopulos, MA; Mitsiades, CS; Anderson, KC; Richardson, PG (2011). "Tanespimitsin antitümör davolash sifatida". Klinik lenfoma, miyeloma va leykemiya. 11 (1): 17–22. doi:10.3816 / CLML.2011.n.002. PMID 21454186.

[2] ttp://www.clinicaltrials.gov/ct/show/NCT00093821 1-bosqich sinovi: 17-N-Allylamino-17-Demetoksigeldanamitsin (17-AAG) yosh bemorlarni takroriy yoki refrakter leykemiya yoki qattiq o'smalar bilan davolashda

[3] ttp://www.clinicaltrials.gov/ct/show/NCT00079404 1-bosqich sinovi: 17-N-Allylamino-17-Demetoksigeldanamitsin relapsli yoki refrakter qattiq o'smalar yoki leykemiya bilan kasallangan yosh bemorlarni davolashda.

[available-4] "Bristol-Myers Skvib tanespimitsinni ishlab chiqarishni to'xtatdi".

[1]

[2]

[3]

[4]

Ismlar

IUPAC nomi [(3S,5S,6R,7S,8E,10R,11S,12E,14E) -21- (allilamino) -6-gidroksi-5,11-dimetoksi-3,7,9,15-tetrametil-16,20,22-trioxo-17-azabitsiklo [16.3.1] docosa-8,12, 14,18,21-pentaen-10-yl] karbamat
Boshqa ismlar 17-N-Allilino-17-demetoksigeldanamitsin 17-AAG
Identifikatorlar
CAS raqami	75747-14-7^N
3D model (JSmol )	Interaktiv rasm Interaktiv rasm
ChEMBL	ChEMBL109480^Y
ChemSpider	21106220^Y
IUPHAR / BPS	7751
PubChem CID	6440175
UNII	4GY0AVT3L4^Y
CompTox boshqaruv paneli (EPA)	DTXSID5046352
InChI InChI = 1S / C31H43N3O8 / c1-8-12-33-26-21-13-17 (2) 14-25 (41-7) 27 (36) 19 (4) 15-20 (5) 29 (42-) 31 (32) 39) 24 (40-6) 11-9-10-18 (3) 30 (38) 34-22 (28 (21) 37) 16-23 (26) 35 / h8-11,15-) 17,19,24-25,27,29,33,36H, 1,12-14H2,2-7H3, (H2,32,39) (H, 34,38) / b11-9-, 18-10 + , 20-15 + / t17-, 19 +, 24 +, 25 +, 27-, 29 + / m1 / s1^Y Kalit: AYUNIORJHRXIBJ-TXHRRWQRSA-N^Y InChI = 1 / C31H43N3O8 / c1-8-12-33-26-21-13-17 (2) 14-25 (41-7) 27 (36) 19 (4) 15-20 (5) 29 (42-) 31 (32) 39) 24 (40-6) 11-9-10-18 (3) 30 (38) 34-22 (28 (21) 37) 16-23 (26) 35 / h8-11,15-) 17,19,24-25,27,29,33,36H, 1,12-14H2,2-7H3, (H2,32,39) (H, 34,38) / b11-9-, 18-10 + , 20-15 + / t17-, 19 +, 24 +, 25 +, 27-, 29 + / m1 / s1 Kalit: AYUNIORJHRXIBJ-TXHRRWQRBY
Jilmayganlar NC (= O) O [C @ H] 1C (/ C) = C / [C @ H] (C) [C @@ H] (O) [C @@ H] (OC) C [C @ H ] (C) C C2 = C (/ NCC = C) C (= O) C = C ( NC (= O) C ( C) = C C = C / [C @@ H] 1OC ) C2 = O C [C @ H] 1C [C @@ H] ([C @@ H] ([C @ H] (/ C = C (/ [C @@ H) ([C @ H] (/ C = C C = C ( C (= O) NC2 = CC (= O) C (= C (C1) C2 = O) NCC = C) / C) OC) OC (= O) N) C) C) O) OC
Xususiyatlari
Kimyoviy formulalar	C₃₁H₄₃N₃O₈
Molyar massa	585.698 g · mol⁻¹
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
N tasdiqlang (nima bu ^YN ?)
Infobox ma'lumotnomalari