Voxilaprevir - Voxilaprevir

Voxilaprevir
Klinik ma'lumotlar
Savdo nomlari	Vosevi (bilan birikmasi sofosbuvir va velpatasvir )
Identifikatorlar
	IUPAC nomi (1R,18R,20R,24S,27S,28S)-N-[(1R,2R) -2- (Diflorometil) -1 - {[(1-metilsiklopropil) sulfanil] karbamoil} siklopropil] -28-etil-13,13-difloro-7-metoksi-24- (2-metil-2-propanil) - 22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo [24.2.1.03,12.05,10.018,20] nonakoza-3 (12), 4,6,8,10-pentaen-27-karboksamid;
CAS raqami	1535212-07-7;
PubChem CID	89921642;
ChemSpider	44209500;
UNII	0570F37359;
KEGG	D10899;
PDB ligand	L9P (PDBe, RCSB PDB);
Kimyoviy va fizik ma'lumotlar
Formula	C40H52F4N6O9S
Molyar massa	868.94 g · mol−1
3D model (JSmol )	;
Zichlik	1.4±0.1 g / sm3
	Jilmayganlar CC [C @@ H] 1 [C @@ H] 2CN ([C @@ H] 1C (= O) N [C @@] 3 (C [C @ H] 3C (F) F) C (= O) NS (= O) (= O) C4 (CC4) C) C (= O) [C @@ H] (NC (= O) O [C @@ H] 5C [C @ H] 5CCCCC (c6c) (nc7cc (ccc7n6) OC) O2) (F) F) C (C) (C) C;
	InChI InChI = 1S / C40H52F4N6O9S / c1-7-22-27-19-50 (28 (22) 32 (51) 48-39 (18-23 (39) 31 (41) 42) 35 (53) 49-60) 55,56) 38 (5) 14-15-38) 34 (52) 30 (37 (2,3) 4) 47-36 (54) 59-26-16-20 (26) 10-8-9- 13-40 (43,44) 29-33 (58-27) 46-25-17-21 (57-6) 11-12-24 (25) 45-29 / h11-12,17,20,22- 23,26-28,30-31H, 7-10,13-16,18-19H2,1-6H3, (H, 47,54) (H, 48,51) (H, 49,53) / t20- , 22-, 23 +, 26-, 27 +, 28 +, 30-, 39- / m1 / s1; Kalit: MZBLZLWXUBZHSL-FZNJKFJKSA-N;

Voxilaprevir a gepatit C virusi (HCV) tarkibiy bo'lmagan (NS) oqsil 3 /4A proteaz inhibitori (tomonidan Gilad ) bilan birgalikda ishlatiladi sofosbuvir va velpatasvir. Kombinatsiya savdo nomiga ega Vosevi va evropalikdan ijobiy fikr oldi Inson foydalanishi uchun tibbiy mahsulotlar qo'mitasi 2017 yil iyun oyida.^[2]

2017 yil 18-iyulda Vosevi tomonidan tasdiqlangan Oziq-ovqat va dori-darmonlarni qabul qilish.^[3]

Adabiyotlar

Bu infektsiyaga qarshi dori maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.