Apitsidin - Apicidin

Apitsidin
Ismlar
	IUPAC nomi (3S,6S,9S, 15aR)-9-[(2S) -2-Butanil] -6 - [(1-metoksi-1H-indol-3-yl) metil] -3- (6-oksooktil) oktahidro-2H-pirido [1,2-a] [1,4,7,10] tetraazasiklododesin-1,4,7,10 (3H,12H) -tetron
Identifikatorlar
CAS raqami	183506-66-3;
3D model (JSmol )	Interaktiv rasm;
ChemSpider	5293532;
ECHA ma'lumot kartasi	100.163.614
IUPHAR / BPS	7495;
PubChem CID	6918328;
CompTox boshqaruv paneli (EPA)	DTXSID40274182 ;
	InChI InChI = 1S / C34H49N5O6 / c1-5-22 (3) 30-34 (44) 38-19-13-12-18-29 (38) 33 (43) 35-26 (16-9-7-8-) 14-24 (40) 6-2) 31 (41) 36-27 (32 (42) 37-30) 20-23-21-39 (45-4) 28-17-11-10-15-25 ( 23) 28 / h10-11,15,17,21-22,26-27,29-30H, 5-9,12-14,16,18-20H2,1-4H3, (H, 35,43) ( H, 36,41) (H, 37,42) / t22-, 26-, 27-, 29 +, 30- / m0 / s1 Kalit: JWOGUUIOCYMBPV-GMFLJSBRSA-N; InChI = 1 / C34H49N5O6 / c1-5-22 (3) 30-34 (44) 38-19-13-12-18-29 (38) 33 (43) 35-26 (16-9-7-8-) 14-24 (40) 6-2) 31 (41) 36-27 (32 (42) 37-30) 20-23-21-39 (45-4) 28-17-11-10-15-25 ( 23) 28 / h10-11,15,17,21-22,26-27,29-30H, 5-9,12-14,16,18-20H2,1-4H3, (H, 35,43) ( H, 36,41) (H, 37,42) / t22-, 26-, 27-, 29 +, 30- / m0 / s1 Kalit: JWOGUUIOCYMBPV-GMFLJSBRBJ;
	Jilmayganlar CC [C @ H] (C) [C @ H] 1C (= O) N2CCCC [C @@ H] 2C (= O) N [C @ H] (C (= O) N [C @ H]) C (= O) N1) CC3 = CN (C4 = CC = CC = C43) OC) CCCCCC (= O) CC;
Xususiyatlari
Kimyoviy formulalar	C34H49N5O6
Molyar massa	623.795 g · mol−1
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	Infobox ma'lumotnomalari

Apitsidin qo'ziqorin metabolitidir, shuningdek giston deatsetilaza inhibitori.^[1]

Adabiyotlar

^ "Apitsidin, histon deatsetilaza inhibitori, p21WAF1 / Cip1 va gelsolin induksiyasi orqali o'sma hujayralarining ko'payishini inhibe qiladi". Saraton kasalligi. 60 (21): 6068-74. 2000 yil noyabr. PMID 11085529.

Haqida ushbu maqola organik birikma a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[1] "Apitsidin, histon deatsetilaza inhibitori, p21WAF1 / Cip1 va gelsolin induksiyasi orqali o'sma hujayralarining ko'payishini inhibe qiladi". Saraton kasalligi. 60 (21): 6068-74. 2000 yil noyabr. PMID 11085529.

[1]

Ismlar

IUPAC nomi (3S,6S,9S, 15aR)-9-[(2S) -2-Butanil] -6 - [(1-metoksi-1H-indol-3-yl) metil] -3- (6-oksooktil) oktahidro-2H-pirido [1,2-a] [1,4,7,10] tetraazasiklododesin-1,4,7,10 (3H,12H) -tetron
Identifikatorlar
CAS raqami	183506-66-3
3D model (JSmol )	Interaktiv rasm
ChemSpider	5293532
ECHA ma'lumot kartasi	100.163.614
IUPHAR / BPS	7495
PubChem CID	6918328
CompTox boshqaruv paneli (EPA)	DTXSID40274182
InChI InChI = 1S / C34H49N5O6 / c1-5-22 (3) 30-34 (44) 38-19-13-12-18-29 (38) 33 (43) 35-26 (16-9-7-8-) 14-24 (40) 6-2) 31 (41) 36-27 (32 (42) 37-30) 20-23-21-39 (45-4) 28-17-11-10-15-25 ( 23) 28 / h10-11,15,17,21-22,26-27,29-30H, 5-9,12-14,16,18-20H2,1-4H3, (H, 35,43) ( H, 36,41) (H, 37,42) / t22-, 26-, 27-, 29 +, 30- / m0 / s1 Kalit: JWOGUUIOCYMBPV-GMFLJSBRSA-N InChI = 1 / C34H49N5O6 / c1-5-22 (3) 30-34 (44) 38-19-13-12-18-29 (38) 33 (43) 35-26 (16-9-7-8-) 14-24 (40) 6-2) 31 (41) 36-27 (32 (42) 37-30) 20-23-21-39 (45-4) 28-17-11-10-15-25 ( 23) 28 / h10-11,15,17,21-22,26-27,29-30H, 5-9,12-14,16,18-20H2,1-4H3, (H, 35,43) ( H, 36,41) (H, 37,42) / t22-, 26-, 27-, 29 +, 30- / m0 / s1 Kalit: JWOGUUIOCYMBPV-GMFLJSBRBJ
Jilmayganlar CC [C @ H] (C) [C @ H] 1C (= O) N2CCCC [C @@ H] 2C (= O) N [C @ H] (C (= O) N [C @ H]) C (= O) N1) CC3 = CN (C4 = CC = CC = C43) OC) CCCCCC (= O) CC
Xususiyatlari
Kimyoviy formulalar	C₃₄H₄₉N₅O₆
Molyar massa	623.795 g · mol⁻¹
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
Infobox ma'lumotnomalari