Dikloroizoprenalin - Dichloroisoprenaline

Dikloroizoprenalin
Ismlar

IUPAC nomi afzal 1- (3,4-Diklorofenil) -2 - [(propan-2-il) amino] etan-1-ol
Boshqa ismlar 1- (3,4-Diklorofenil) -2- (izopropilamino) etanol Diklorisoproterenol
Identifikatorlar
CAS raqami	59-61-0^Y
3D model (JSmol )	Interaktiv rasm Interaktiv rasm
ChEBI	CHEBI: 144234^N
ChEMBL	ChEMBL30816^Y
ChemSpider	5601 (1R)^Y 5324297 (1S)^Y 5601 ()^Y
KEGG	FZR 7272^N
MeSH	Dikloroizoproterenol
PubChem CID	5806 (1R) 6951395 (1S) 5806 ()
UNII	U7NOE2K4M2^Y
CompTox boshqaruv paneli (EPA)	DTXSID20874225
InChI InChI = 1S / C11H15Cl2NO / c1-7 (2) 14-6-11 (15) 8-3-4-9 (12) 10 (13) 5-8 / h3-5,7,11,14-15H, 6H2,1-2H3^Y Kalit: VKMGSWIFEHZQRS-UHFFFAOYSA-N^Y InChI = 1 / C11H15Cl2NO / c1-7 (2) 14-6-11 (15) 8-3-4-9 (12) 10 (13) 5-8 / h3-5,7,11,14-15H, 6H2,1-2H3 Kalit: VKMGSWIFEHZQRS-UHFFFAOYAS
Jilmayganlar CC (C) NCC (O) C1 = CC (Cl) = C (Cl) C = C1 Clc1ccc (cc1Cl) C (O) CNC (C) C
Xususiyatlari
Kimyoviy formulalar	C₁₁H₁₅Cl₂YOQ
Molyar massa	248,15 g / mol
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar berilgan standart holat (25 ° C [77 ° F], 100 kPa da).
N tasdiqlang (nima bu ^YN ?)
Infobox ma'lumotnomalari

Dikloroizoprenalin (DCI), shuningdek, nomi bilan tanilgan dikloroizoproterenol, birinchi bo'ldi beta bloker har doim ishlab chiqilishi kerak. Uchun tanlanmagan β₁-adrenerjik va β₂-adrenergik retseptorlari. DCI past kuch va a vazifasini bajaradi qisman agonist /antagonist bularda retseptorlari.^[1]

DCI ning o'zi klinik ahamiyatga ega bo'lmasa-da, DCI ning keyingi rivojlanishi klinik nomzodning rivojlanishiga olib keldi pronetalol (tufayli qaytarib olingan kanserogenlik ) va keyinchalik propranolol (birinchi klinik jihatdan muvaffaqiyatli bo'lgan beta bloker).

Dichloroisoprenaline - enantiomerlarning rasemik aralashmasi.

Dikloroizoprenalinning ikkita enantiomeri

Adabiyotlar

^ V. E. Glover; A. D. M. Grinfild; R. G. Shanks (1962 yil oktyabr). "Dikloroizoprenalinning odamdagi adrenalinga periferik qon tomir reaktsiyalariga ta'siri". Br J Pharmacol Chemother. 19 (2): 235–244. doi:10.1111 / j.1476-5381.1962.tb01185.x. PMC 1482134. PMID 13948521.

Adrenergik retseptorlari modulyatorlar
a₁	Agonistlar: 6-FNE Amidefrin Anizodin Buspirone Sirazolin Korbadrin Desglimidodrin Deksisometheptene Dipivefrin Dopamin Droksidopa (L-DOPS) Efedrin Epinefrin Etilefrin Etilevodopa Etilnorepinefrin Indanidin Izometheptene L-DOPA (levodopa) L-Fenilalanin L-Tirozin Melevodopa Metaraminol Metoksamin Metildopa Midodrin Nafazolin Norepinefrin Ahtapamin Oksimetazolin Fenilefrin Fenilpropanolamin Psödoefedrin Sinefrin Tetrizolin Tiamenidin XP21279 Ksilometazolin Antagonistlar: Abanquil Adimolol Ajmalitsin Alfuzosin Amosulalol Anizodamin Arotinolol Atiprosin Atipik antipsikotiklar (masalan, brekspiprazol, klozapin, olanzapin, ketiapin, risperidon ) Benoksatian Buflomedil Bunazosin Carvedilol Korynantin Dapiprazol Mahalliy Doksazosin Ergolines (masalan, ergotamin, dihidroergotamin, lisurid, tergurid ) Etoperidon Evgenodilol Fenspirid Gidroksizin Indoramin Ketanserin L-765,314 Labetalol mCPP Mepiprazol Metazosin Monatepil Moksisilit Naftopidil Nantenin Neldazosin Niaprazin Nikergolin Niguldipine Pardoprunoks Pelanserin Perlapin Phendioxan Fenoksibenzamin Fentolamin Fenilpiperazin antidepressantlar (masalan, gidroksifazodon, nefazodon, trazodon, triazoledion ) Piperoksan Prazosin Kinazosin Kinidin Ritanserin Silodosin Spiperon Talipeksol Tamsulosin Terazosin Tiodazosin Tolazolin Tetratsiklik antidepressantlar (masalan, amoksapin, maprotilin, mianserin ) Trisiklik antidepressantlar (masalan, amitriptilin, klomipramin, doksepin, imipramin, trimipramin ) Trimazosin Odatda antipsikotiklar (masalan, xlorpromazin, flüfenazin, loxapin, tioridazin ) Urapidil WB-4101 Zolertin
a₂	Agonistlar: (R) -3-nitrobifenilin 4-NEMD 6-FNE Amitraz Apraklonidin Brimonidin Kannabivarin Klonidin Korbadrin Detomidin Deksmedetomidin Dihidroergotamin Dipivefrin Dopamin Droksidopa (L-DOPS) Etilevodopa Efedrin Ergotamin Epinefrin Etilefrin Etilnorepinefrin Guanabenz Guanfasin Guanoksabenz L-DOPA (levodopa) L-Fenilalanin L-Tirozin Lofexidin Medetomidin Melevodopa Metildopa Mivazerol Nafazolin Norepinefrin Oksimetazolin Fenilpropanolamin Piperoksan Psödoefedrin Rezatomidin Rilmenidin Romifidin Talipeksol Tasipimidin Tetrahidrozolin Tiamenidin Tizanidin Tolonidin Urapidil Vatinoksan XP21279 Ksilazin Ksilometazolin Antagonistlar: 1-PP Adimolol Amesergid Aptazapin Atipamezol Atipik antipsikotiklar (masalan, asenapin, brekspiprazol, klozapin, lurasidon, olanzapin, paliperidon, ketiapin, risperidon, zotepin ) Azapironlar (masalan, buspirone, gepiron, ipsapirone, tandospiron ) BRL-44408 Buflomedil Sirazolin Efaroksan Esmirtazapin Fenmetozol Fluparoksan Idazoksan mCPP Mianserin Mirtazapin NAN-190 Pardoprunoks Fentolamin Fenoksibenzamin Piperoksan Piribedil Rawolscine Rotigotin SB-269970 Setiptiline Spiroksatrin Sunepitron Tolazolin Odatda antipsikotiklar (masalan, xlorpromazin, flüfenazin, loxapin, tioridazin ) Yohimbine
β	Agonistlar: Abediterol Alifedrin Amibegron Arbutamin Arformoterol Arotinolol BAAM Bambuterol Befunolol Bitolterol Broksaterol Bupenin Karbuterol Karmoterol Cimaterol Klenbuterol Kolterol Korbadrin Denopamin Dipivefrin Dobutamin Dopamin Dopeksamin Droksidopa (L-DOPS) Efedrin Epinefrin Etafedrin Etilefrin Etilevodopa Etilnorepinefrin Fenoterol Formoterol Geksoprenalin Higenamin Indakaterol Isoetarin Izoprenalin Isoxsuprine L-DOPA (levodopa) L-Fenilalanin L-Tirozin Levosalbutamol Mabuterol Melevodopa Metoksifenamin Metildopa Mirabegron Norepinefrin Orsiprenalin Oksifedrin PF-610355 Fenilpropanolamin Pirbuterol Prenalterol Raktopamin Prokaterol Psödoefedrin Reproterol Rimiterol Ritodrin Salbutamol Salmeterol Solabegron Terbutalin Tretoxinol Tulobuterol Vilanterol Xamoterol XP21279 Zilpaterol Zinterol Antagonistlar: Asebutolol Adaprolol Adimolol Afurolol Alprenolol Alprenoksim Amosulalol Ancarolol Arnolol Arotinolol Atenolol Befunolol Betaxolol Bevantolol Bisoprolol Bopindolol Bornaprolol Brefonalol Bucindolol Bucumolol Bufetolol Bufuralol Bunitrolol Bunolol Bupranolol Butaksamin Butidrin Butofilolol Kapsinolol Karazolol Karpindolol Karteolol Carvedilol Celiprolol Setamolol Tsikloprolol Cinamolol Kloranol Siyanopindolol Dalbraminol Dexpropranolol Diatsetolol Dikloroizoprenalin Dihidroalprenolol Dilevalol Diprafenon Drakinolol Ecastolol Epanolol Erikolol Ersentilid Esatenolol Esprolol Evgenodilol Exaprolol Falintolol Flestolol Flusoksolol Gidroksikarteolol Gidroksistertolol ICI-118,551 Idropranolol Indenolol Indopanolol Iodosiyanopindolol Iprokrolol Isoxaprolol Isamoltan Labetalol Landiolol Levobetaxolol Levobunolol Levomoprolol Medroxalol Mepindolol Metipranolol Metoprolol Moprolol Nadolol Nadoksolol Nebivolol Nifenalol Nipradilol Oksprenolol Pakrinolol Pafenolol Pamatolol Pargolol Penbutolol Pindolol Practolol Primidolol Protsinolol Pronetalol Propafenon Propranolol Ridazolol Ronaktolol Soquinolol Sotalol Spirendolol SR 59230A Sulfinalol Talinolol Tazolol Tertatolol Tienoksolol Tilisolol Timolol Tiprenolol Tolamolol Toliprolol Xibenolol Xipranolol
Qarang shuningdek	Adrenerjik dorilar ro'yxati

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