Digitonin - Digitonin

Digitonin
	; Raqitoninning kimyoviy tuzilishi
	; Shakar qisqartmalaridan foydalanib alternativ tasvir (Gal = galaktoza, Glc = glyukoza, Xyl = ksiloza
Ismlar
	Boshqa ismlar Digitin
Identifikatorlar
CAS raqami	11024-24-1 ;
3D model (JSmol )	Interaktiv rasm;
ChEMBL	ChEMBL404811 ;
ChemSpider	23753 ;
ECHA ma'lumot kartasi	100.031.129
EC raqami	234-255-6;
KEGG	C00765 ;
PubChem CID	25444;
UNII	KOO5CM684H ;
CompTox boshqaruv paneli (EPA)	DTXSID1025065 ;
	InChI InChI = 1S / C56H92O29 / c1-19-7-10-56 (75-17-19) 20 (2) 31-45 (85-56) 37 (67) 32-22-6-5-21-11- 26 (24 (61) 12-55 (21,4) 23 (22) 8-9-54 (31,32) 3) 76-50-42 (72) 39 (69) 44 (30 (16-60)) 80-50) 81-53-48 (47 (36 (66) 29 (15-59) 79-53) 83-49-40 (70) 33 (63) 25 (62) 18-74-49) 84-) 52-43 (73) 46 (35 (65) 28 (14-58) 78-52) 82-51-41 (71) 38 (68) 34 (64) 27 (13-57) 77-51 / h19- 53,57-73H, 5-18H2,1-4H3 / t19-, 20 +, 21 +, 22-, 23 +, 24-, 25-, 26-, 27-, 28-, 29-, 30-, 31 +, 32-, 33 +, 34-, 35 +, 36?, 37 +, 38 +, 39-, 40-, 41-, 42-, 43-, 44 +, 45-, 46 +, 47 + , 48-, 49 +, 50-, 51 +, 52 +, 53 +, 54-, 55 +, 56- / m1 / s1 Kalit: UVYVLBIGDKGWPX-YCCXZQINSA-N ; InChI = 1 / C56H92O29 / c1-19-7-10-56 (75-17-19) 20 (2) 31-45 (85-56) 37 (67) 32-22-6-5-21-11- 26 (24 (61) 12-55 (21,4) 23 (22) 8-9-54 (31,32) 3) 76-50-42 (72) 39 (69) 44 (30 (16-60)) 80-50) 81-53-48 (47 (36 (66) 29 (15-59) 79-53) 83-49-40 (70) 33 (63) 25 (62) 18-74-49) 84-) 52-43 (73) 46 (35 (65) 28 (14-58) 78-52) 82-51-41 (71) 38 (68) 34 (64) 27 (13-57) 77-51 / h19- 53,57-73H, 5-18H2,1-4H3 / t19-, 20 +, 21 +, 22-, 23 +, 24-, 25-, 26-, 27-, 28-, 29-, 30-, 31 +, 32-, 33 +, 34-, 35 +, 36?, 37 +, 38 +, 39-, 40-, 41-, 42-, 43-, 44 +, 45-, 46 +, 47 + , 48-, 49 +, 50-, 5 1 +, 52 +, 53 +, 54-, 55 +, 56- / m1 / s1;
	Jilmayganlar O [C @@ H]% 11 [C @@ H] (O) [C @ H] (O) [C @ H] (O [C @ H]% 11O [C @@ H] 1 [C @ @H] (O) [C @@ H] (O [C @ H] (CO) [C @@ H] 1O) O [C @@ H]% 10 [C @@ H] (O [C @ @H] 2OC [C @@ H] (O) [C @ H] (O) [C @ H] 2O) C (O) [C @ H] (O [C @ H]% 10O [C @@ H] 3 [C @ H] (O) [C @@ H] (O) [C @@ H] (O [C @@ H] 3CO) O [C @ H] 9 [C @ H] (O ) C [C @@] 8 (C) [C @@ H] (CC [C @@ H] 6 [C @@ H] 8CC [C @@] 7 ([C @@ H] 5 [C @ @H] (O [C @@] 4 (OC [C @@ H] (CC4) C) [C @ H] 5C) [C @@ H] (O) [C @@ H] 67) C) C9) CO) CO;
Xususiyatlari
Kimyoviy formulalar	C56H92O29
Molyar massa	1229.323 g · mol−1
Tashqi ko'rinishi	Oqdan oq ranggacha kukun
Erish nuqtasi	244.0-248.5 ° S (471.2-479.3 ° F; 517.1-521.6 K)
Chiralning aylanishi ([a]D.)	-40 ° (589,3 nm; 20 ° C)
Xavf
	O'lim dozasi yoki konsentratsiyasi (LD, LC):
LD50 (o'rtacha doz )	23 mg / kg (kalamush, vena ichiga) 4 mg / kg (sichqoncha, vena ichiga)
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	tasdiqlang (nima bu ?)
	Infobox ma'lumotnomalari

Digitonin steroidaldir saponin (saraponin) foxglove o'simlikidan olingan Digitalis purpurea. Uning aglikon bu raqamogenin, a spirostan steroid. U detarjan sifatida o'rganilgan, chunki u samarali suvda eritiladi lipidlar. Shunday qilib, u bir nechta potentsialga ega membrana bilan bog'liq dasturlar biokimyo shu jumladan erituvchi membrana oqsillari, cho'ktiruvchi xolesterin va hujayra membranalarini o'tkazuvchanligi.^[4]^[5]

Digitonin ba'zan bilan aralashtiriladi yurak giyohvand moddalar digoksin va digitoksin va uchalasini ham bitta manbadan olish mumkin.

Kimyoviy xususiyatlari

Kritik misel konsentratsiyasi = <0,5 mm
O'rtacha misel massasi = 70000
Birlashma raqami = 60

Adabiyotlar

^ ^a ^b Tscheche, R .; Vulf, G. (1963 yil yanvar). "Über saponine der spirostanolreihe — IX". Tetraedr (nemis tilida). 19 (4): 621–634. doi:10.1016 / S0040-4020 (01) 98548-5.
^ Segal, Rut; Milo-Goldtsvayg, Ilana; Kaplan, Gideon; Vaysenberg, Emil (1977 yil aprel). "Glisirrizinning saponin toksikligiga qarshi himoya ta'siri". Biokimyoviy farmakologiya. 26 (7): 643–645. doi:10.1016/0006-2952(77)90039-9.
^ Pita, Yozef; Szente, Lajos (1984 yil fevral). "Past toksiklikka ega bo'lgan digitonin hosilalari: Lipofil birikmalari uchun potentsial erituvchi moddalar". Farmatsevtika fanlari jurnali. 73 (2): 240–243. doi:10.1002 / jps.2600730224.
^ Geelen, matematik J.H. (2005 yil dekabr). "Lipit metabolizmi bo'yicha tadqiqotlar davomida fermentlar faolligini o'lchash uchun raqamonin-o'tkazuvchan sutemizuvchi hujayralardan foydalanish". Analitik biokimyo. 347 (1): 1–9. doi:10.1016 / j.ab.2005.03.032. PMID 16291302.
^ Fiskum, Gari (1985 yil aprel). "Hujayra ichidagi darajalar va Ca2 + ning dijitalonin o'tkazuvchan hujayralarida tarqalishi". Hujayra kaltsiy. 6 (1–2): 25–37. doi:10.1016/0143-4160(85)90032-6.

[Wulff-1] Tscheche, R .; Vulf, G. (1963 yil yanvar). "Über saponine der spirostanolreihe — IX". Tetraedr (nemis tilida). 19 (4): 621–634. doi:10.1016 / S0040-4020 (01) 98548-5.

[2] Segal, Rut; Milo-Goldtsvayg, Ilana; Kaplan, Gideon; Vaysenberg, Emil (1977 yil aprel). "Glisirrizinning saponin toksikligiga qarshi himoya ta'siri". Biokimyoviy farmakologiya. 26 (7): 643–645. doi:10.1016/0006-2952(77)90039-9.

[3] Pita, Yozef; Szente, Lajos (1984 yil fevral). "Past toksiklikka ega bo'lgan digitonin hosilalari: Lipofil birikmalari uchun potentsial erituvchi moddalar". Farmatsevtika fanlari jurnali. 73 (2): 240–243. doi:10.1002 / jps.2600730224.

[4] Geelen, matematik J.H. (2005 yil dekabr). "Lipit metabolizmi bo'yicha tadqiqotlar davomida fermentlar faolligini o'lchash uchun raqamonin-o'tkazuvchan sutemizuvchi hujayralardan foydalanish". Analitik biokimyo. 347 (1): 1–9. doi:10.1016 / j.ab.2005.03.032. PMID 16291302.

[5] Fiskum, Gari (1985 yil aprel). "Hujayra ichidagi darajalar va Ca2 + ning dijitalonin o'tkazuvchan hujayralarida tarqalishi". Hujayra kaltsiy. 6 (1–2): 25–37. doi:10.1016/0143-4160(85)90032-6.

[1]

[2]

[3]

[4]

[5]

Glikozidlar
Obligatsiya	O-glikozid birikmasi N-glikozid birikmasi S-glikozid bog'lanish C-glikozid birikmasi
Geometriya	a-glikozid b-glikozid 1,4-glikozid 1,6-glikozid
Glikon	Fruktozid Galaktozid Glyukozid Glyukuronid Ramnosid Ribozid
Aglikon	Alkogolli glikozid Yurak glikozidi Bufadienolid Kardenolid Siyanogen glikozid Glikosilamin Fenolik glikozid Antrakinon glikozidi Kumarin glikozidi Flavonoid glikozid Saponin Steviol glikozidi Tioglikozid

Ismlar
Raqitoninning kimyoviy tuzilishi
Shakar qisqartmalaridan foydalanib alternativ tasvir (Gal = galaktoza, Glc = glyukoza, Xyl = ksiloza
Boshqa ismlar Digitin
Identifikatorlar
CAS raqami	11024-24-1^Y
3D model (JSmol )	Interaktiv rasm
ChEMBL	ChEMBL404811^N
ChemSpider	23753^Y
ECHA ma'lumot kartasi	100.031.129
EC raqami	234-255-6
KEGG	C00765^N
PubChem CID	25444
UNII	KOO5CM684H^Y
CompTox boshqaruv paneli (EPA)	DTXSID1025065
InChI InChI = 1S / C56H92O29 / c1-19-7-10-56 (75-17-19) 20 (2) 31-45 (85-56) 37 (67) 32-22-6-5-21-11- 26 (24 (61) 12-55 (21,4) 23 (22) 8-9-54 (31,32) 3) 76-50-42 (72) 39 (69) 44 (30 (16-60)) 80-50) 81-53-48 (47 (36 (66) 29 (15-59) 79-53) 83-49-40 (70) 33 (63) 25 (62) 18-74-49) 84-) 52-43 (73) 46 (35 (65) 28 (14-58) 78-52) 82-51-41 (71) 38 (68) 34 (64) 27 (13-57) 77-51 / h19- 53,57-73H, 5-18H2,1-4H3 / t19-, 20 +, 21 +, 22-, 23 +, 24-, 25-, 26-, 27-, 28-, 29-, 30-, 31 +, 32-, 33 +, 34-, 35 +, 36?, 37 +, 38 +, 39-, 40-, 41-, 42-, 43-, 44 +, 45-, 46 +, 47 + , 48-, 49 +, 50-, 51 +, 52 +, 53 +, 54-, 55 +, 56- / m1 / s1^N Kalit: UVYVLBIGDKGWPX-YCCXZQINSA-N^N InChI = 1 / C56H92O29 / c1-19-7-10-56 (75-17-19) 20 (2) 31-45 (85-56) 37 (67) 32-22-6-5-21-11- 26 (24 (61) 12-55 (21,4) 23 (22) 8-9-54 (31,32) 3) 76-50-42 (72) 39 (69) 44 (30 (16-60)) 80-50) 81-53-48 (47 (36 (66) 29 (15-59) 79-53) 83-49-40 (70) 33 (63) 25 (62) 18-74-49) 84-) 52-43 (73) 46 (35 (65) 28 (14-58) 78-52) 82-51-41 (71) 38 (68) 34 (64) 27 (13-57) 77-51 / h19- 53,57-73H, 5-18H2,1-4H3 / t19-, 20 +, 21 +, 22-, 23 +, 24-, 25-, 26-, 27-, 28-, 29-, 30-, 31 +, 32-, 33 +, 34-, 35 +, 36?, 37 +, 38 +, 39-, 40-, 41-, 42-, 43-, 44 +, 45-, 46 +, 47 + , 48-, 49 +, 50-, 5 1 +, 52 +, 53 +, 54-, 55 +, 56- / m1 / s1
Jilmayganlar O [C @@ H]% 11 [C @@ H] (O) [C @ H] (O) [C @ H] (O [C @ H]% 11O [C @@ H] 1 [C @ @H] (O) [C @@ H] (O [C @ H] (CO) [C @@ H] 1O) O [C @@ H]% 10 [C @@ H] (O [C @ @H] 2OC [C @@ H] (O) [C @ H] (O) [C @ H] 2O) C (O) [C @ H] (O [C @ H]% 10O [C @@ H] 3 [C @ H] (O) [C @@ H] (O) [C @@ H] (O [C @@ H] 3CO) O [C @ H] 9 [C @ H] (O ) C [C @@] 8 (C) [C @@ H] (CC [C @@ H] 6 [C @@ H] 8CC [C @@] 7 ([C @@ H] 5 [C @ @H] (O [C @@] 4 (OC [C @@ H] (CC4) C) [C @ H] 5C) [C @@ H] (O) [C @@ H] 67) C) C9) CO) CO
Xususiyatlari
Kimyoviy formulalar	C₅₆H₉₂O₂₉
Molyar massa	1229.323 g · mol⁻¹
Tashqi ko'rinishi	Oqdan oq ranggacha kukun
Erish nuqtasi	244.0-248.5 ° S (471.2-479.3 ° F; 517.1-521.6 K)^[1]
Chiralning aylanishi ([a]_D.)	-40 ° (589,3 nm; 20 ° C)^[1]
Xavf
O'lim dozasi yoki konsentratsiyasi (LD, LC):
LD₅₀ (o'rtacha doz )	23 mg / kg (kalamush, vena ichiga)^[2] 4 mg / kg (sichqoncha, vena ichiga)^[3]
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
N tasdiqlang (nima bu ^YN ?)
Infobox ma'lumotnomalari