Foligluraks - Foliglurax - Wikipedia

Foligluraks
Klinik ma'lumotlar
Boshqa ismlar	DT2331; PXT-002331; PXT-2331
Identifikatorlar
	IUPAC nomi 4- [3- [4-nitroso-2- (5H-tieno [3,2-c] piridin-6-iliden) xromen-6-il] propil] morfolin;
PubChem CID	129320518;
ChemSpider	59718537;
Kimyoviy va fizik ma'lumotlar
Formula	C23H23N3O3S
Molyar massa	421.52 g · mol−1
3D model (JSmol )	Interaktiv rasm;
	Jilmayganlar C1COCCN1CCCC2 = CC3 = C (C = C2) OC (= C4C = C5C (= CN4) C = CS5) C = C3N = O;
	InChI InChI = 1S / C23H23N3O3S / c27-25-19-13-22 (20-14-23-17 (15-24-20) 5-11-30-23) 29-21-4-3-16 (12-) 18 (19) 21) 2-1-6-26-7-9-28-10-8-26 / h3-5,11-15,24H, 1-2,6-10H2; Kalit: XHRLGFLGWZIPEE-UHFFFAOYSA-N;

Foligluraks (rivojlanish kodlari nomlari PXT-002331, DT2331) a ijobiy allosterik modulyator ning metabotropik glutamat retseptorlari 4 (mGluR₄) davolash uchun Prexton Therapeutics tomonidan ishlab chiqilmoqda Parkinson kasalligi.^[1]^[2] 2017 yil iyul oyidan boshlab II bosqich klinik sinovlar.^[1]

Boshqa tautomerik foligluraks shakli.

Adabiyotlar

^ ^a ^b "Foligluraks - Lundbek". Adis Insight. Springer Nature Switzerland AG.
^ Yankovich J, Aguilar LG (2008 yil avgust). "Parkinson kasalligini davolashning zamonaviy yondashuvlari". Nöropsikiyatrik kasallik va davolash. 4 (4): 743–57. doi:10.1016 / j.bmcl.2017.07.075. PMC 2536542. PMID 19043519.

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