GHKL domeni - GHKL domain
| Gistidin kinaz-, DNK-giraza B- va HSP90 ga o'xshash ATPaza | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Xamirturushli Hsp90 shaperonining N-terminal domenining tuzilishi.[1] | |||||||||||
| Identifikatorlar | |||||||||||
| Belgilar | HATPase_c | ||||||||||
| Pfam | PF02518 | ||||||||||
| InterPro | IPR003594 | ||||||||||
| Aqlli | HATPase_c | ||||||||||
| SCOP2 | 1ei1 / QOIDA / SUPFAM | ||||||||||
| CDD | CD00075 | ||||||||||
| |||||||||||
The GHKL domeni (Gyrase, Hsp90, Histidin Kinase, MutL ) saqlanib qolgan evolyutsiya hisoblanadi protein domeni.[2]
Ushbu oila tarkibiy jihatdan bog'liqdir ATPase histidin kinaz, B va DSP90 gyraz DNK domenlari. Ushbu domen ATP bilan bog'langan bir nechta oqsillarda uchraydi, masalan: gistidin kinaza, DNK gyraza B, topoizomerazalar,[3] issiqlik zarbasi oqsili HSP90,[4][5][6] fitoxromga o'xshash ATPazalar va DNKning mos kelmaydigan oqsillari. Ushbu oqsil haqida ko'proq ma'lumotni oyning oqsilida topishingiz mumkin: DNK Topoizomeraza.[7]
Subfamilies
A'zolar
- BCKDK
- HSP90AA1, HSP90AB1, HSP90B1
- MLH1, MLH3, MORC1, MORC2, MORC3, MORC4
- PDK1, PDK2, PDK3, PDK4
- PMS1, PMS2, PMS2L1, PMS2L11, PMS2L3, PMS4L
- TOP2A, TOP2B
- TRAP1, TRAP
Adabiyotlar
- ^ Prodromou C, Roe SM, Piper PW, Pearl LH (iyun 1997). "Hsp90 xamirturush xamirturushining N-terminal domenining kristalli tuzilishidagi molekulyar qisqich". Nat. Tuzilishi. Biol. 4 (6): 477–82. doi:10.1038 / nsb0697-477. PMID 9187656. S2CID 38764610.
- ^ Dutta R, Inouye M (2000 yil yanvar). "GHKL, paydo bo'lgan ATPase / kinaz superfamilasi". Biokimyo tendentsiyalari. Ilmiy ish. 25 (1): 24–8. doi:10.1016 / S0968-0004 (99) 01503-0. PMID 10637609.
- ^ Bellon S, Parsons JD, Vey Y, Xayakava K, Swenson LL, Charifson PS, Lippke JA, Aldape R, Gross CH (may 2004). "Escherichia coli Topoisomerase IV ParE Subunit (24 va 43 Kilodaltonlar) ning kristalli tuzilmalari: bitta qoldiq Novobiotsin kuchining Topoizomeraza IV va DNK Girazga qarshi farqlarini belgilaydi". Mikrobga qarshi. Agentlar Chemother. 48 (5): 1856–64. doi:10.1128 / AAC.48.5.1856-1864.2004. PMC 400558. PMID 15105144.
- ^ Immormino RM, Dollins DE, Shaffer PL, Soldano KL, Walker MA, Gewirth DT (oktyabr 2004). "GRP94, Hsp90 chaperone, N-terminal domenidagi Ligand tomonidan konformatsion siljish". J. Biol. Kimyoviy. 279 (44): 46162–71. doi:10.1074 / jbc.M405253200. PMID 15292259.
- ^ Roe SM, Ali MM, Meyer P, Vaughan CK, Panaretou B, Piper PW, Prodromou C, Pearl LH (2004 yil yanvar). "Protein kinaziga xos koxaperon p50 (cdc37) tomonidan Hsp90ni tartibga solish mexanizmi". Hujayra. 116 (1): 87–98. doi:10.1016 / S0092-8674 (03) 01027-4. PMID 14718169. S2CID 797232.
- ^ Rayt L, Barril X, Dymok B, Sheridan L, Surgenor A, Besvik M, Drisdeyl M, Kollier A, Massey A, Devis N, Fink A, Fromont C, Aherne V, Boksall K, Sharp S, Workman P, Xabbard RE (2004 yil iyun). "Purin asosidagi inhibitordagi HSP90 izoformalari bilan bog'lanishidagi tuzilish-faollik munosabatlari". Kimyoviy. Biol. 11 (6): 775–85. doi:10.1016 / j.chembiol.2004.03.033. PMID 15217611.
- ^ McDowall J (2006). "DNK topoizomerazasi". Oyning oqsili. InterPro.
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