Nigeritsin - Nigericin

Nigeritsin
Ismlar
	IUPAC nomi (2R) -2 - [(2R, 3S, 6R) -6 - [[(2S, 4R, 5R, 7R, 9R, 10R) -2 - [(2R, 5S) -5 - [(2R, 3S, 5R) -5 - [(2S, 3S, 5R, 6R) -6-gidroksi-6- (gidroksimetil) -3,5-dimetil-2-tetrahidropiranil] -3-metil-2-tetrahidrofuranil] -5-metil- 2-tetrahidrofuranil] -9-metoksi-2,4,10-trimetil-1,6-dioksaspiro [4.5] dekan-7-yl] metil] -3-metil-2-tetrahidropiranil] propanoik kislota
	Boshqa ismlar Polieterin A, Azalomitsin M, Helixin C, Helix C
Identifikatorlar
CAS raqami	28380-24-7 ;
3D model (JSmol )	Interaktiv rasm;
ChEBI	CHEBI: 7569 ;
ChEMBL	ChEMBL405862 ;
ChemSpider	10196461 ;
ECHA ma'lumot kartasi	100.212.814
PubChem CID	34230;
UNII	RRU6GY95IS ;
CompTox boshqaruv paneli (EPA)	DTXSID9041079 ;
	InChI InChI = 1S / C40H68O11 / c1-21-11-12-28 (46-33 (21) 26 (6) 36 (42) 43) 17-29-18-30 (45-10) 27 (7) 40) 48-29) 25 (5) 19-38 (9,51-40) 32-13-14-37 (8,49-32) 35-23 (3) 16-31 (47-35) 34-22 ( 2) 15-24 (4) 39 (44,20-41) 50-34 / h21-35,41,44H, 11-20H2,1-10H3, (H, 42,43) / t21-, 22-, 23-, 24 +, 25 +, 26 +, 27 +, 28 +, 29 +, 30 +, 31 +, 32 +, 33 +, 34-, 35 +, 37-, 38-, 39-, 40 + / m0 / s1 Kalit: DANUORFCFTYTSZ-SJSJOXFOSA-N ; InChI = 1 / C40H68O11 / c1-21-11-12-28 (46-33 (21) 26 (6) 36 (42) 43) 17-29-18-30 (45-10) 27 (7) 40) 48-29) 25 (5) 19-38 (9,51-40) 32-13-14-37 (8,49-32) 35-23 (3) 16-31 (47-35) 34-22 ( 2) 15-24 (4) 39 (44,20-41) 50-34 / h21-35,41,44H, 11-20H2,1-10H3, (H, 42,43) / t21-, 22-, 23-, 24 +, 25 +, 26 +, 27 +, 28 +, 29 +, 30 +, 31 +, 32 +, 33 +, 34-, 35 +, 37-, 38-, 39-, 40 + / m0 / s1 Kalit: DANUORFCFTYTSZ-SJSJOXFOBS;
	Jilmayganlar OC (= O) [C @ H] (C) [C @@ H] 1O [C @ H] (CC [C @@ H] 1C) C [C @ H] 6O [C @] 2 (O [ C @@] (C) (C [C @ H] 2C) [C @ H] 3CC [C @] (C) (O3) [C @@ H] 4O [C @ H] (C [C @@) H] 4C) [C @ H] 5O [C @@] (O) (CO) [C @ H] (C) C [C @@ H] 5C) [C @ H] (C) [C @ H ] (OC) C6;
Xususiyatlari
Kimyoviy formulalar	C40H68O11
Molyar massa	724,96132 g / mol
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar berilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	tasdiqlang (nima bu ?)
	Infobox ma'lumotnomalari

Nigeritsin bu antibiotik dan olingan Streptomyces hygroscopicus. Uning izolyatsiyasi 1950-yillarda tasvirlangan,^[1] va 1968 yilda bu tuzilmani tushuntirish mumkin edi Rentgenologik kristallografiya.^[2] Nigeritsinning tuzilishi va xossalari o'xshash antibiotik monensin. Savdoda u fermentatsiya paytida yon mahsulot yoki ifloslantiruvchi moddalar sifatida olinadi Geldanamitsin. Bundan tashqari, u Polyetherin A, Azalomycin M, Helixin C, Antibiotik K178, Antibiotik X-464 deb nomlanadi.

Nigeritsin H kabi ishlaydi⁺, K⁺, Pb²⁺ ionofor. Odatda bu antiporter H ning⁺ va K⁺.

Ilgari nigeritsin qarshi antibiotik sifatida ishlatilgan gramm ijobiy bakteriyalar. Bu inhibe qiladi Golgi eukaryotik hujayralardagi funktsiyalar. K ni qo'zg'atish qobiliyati⁺ efflux shuningdek uni faollashtiruvchiga aylantiradi NLRP3 yallig'lanish^[3]^[4]

Adabiyotlar

^ Graven SN, Estrada-O S, Lardi XA (1966). "Sichqoncha jigar mitoxondriyasida nigeritsin ta'sirida ishqoriy metal kationining chiqarilishi va nafas olish inhibatsiyasi". Proc. Natl. Akad. Ilmiy ish. AQSH. 56 (2): 654–8. Bibcode:1966 yil PNAS ... 56..654G. doi:10.1073 / pnas.56.2.654. PMC 224422. PMID 5229984.
^ Steinrauf LK, Pinkerton M, Chamberlin JW (1968). "Nigeritsinning tuzilishi". Biokimyo. Biofiz. Res. Kommunal. 33 (1): 29–31. doi:10.1016 / 0006-291X (68) 90249-0. PMID 5696503.
^ Mariathasan, S; Vayss, DS; Nyuton, K; McBride, J; O'Rourke, K; Ruz-Girma, M; Li, WP; Vaynrauch, Y; Monak, DM; Dixit, VM (2006 yil 9 mart). "Kriyopirin toksinlar va ATPga javoban yallig'lanishni faollashtiradi". Tabiat. 440 (7081): 228–32. Bibcode:2006 yil natur.440..228M. doi:10.1038 / tabiat04515. PMID 16407890.
^ Muñoz-Planillo, R; Kuffa, P; Martines-Kolon, G; Smit, BL; Rajendiran, TM; Nunez, G (2013 yil 27-iyun). "K⁺ efflux - bu bakterial toksinlar va zarrachalar ta'sirida NLRP3 inflammasom faollashuvining umumiy qo'zg'atuvchisi". Immunitet. 38 (6): 1142–53. doi:10.1016 / j.immuni.2013.05.016. PMC 3730833. PMID 23809161.

Tashqi havolalar

Nigeritsin natriyining tijorat etkazib beruvchisi

[pmid5229984-1] Graven SN, Estrada-O S, Lardi XA (1966). "Sichqoncha jigar mitoxondriyasida nigeritsin ta'sirida ishqoriy metal kationining chiqarilishi va nafas olish inhibatsiyasi". Proc. Natl. Akad. Ilmiy ish. AQSH. 56 (2): 654–8. Bibcode:1966 yil PNAS ... 56..654G. doi:10.1073 / pnas.56.2.654. PMC 224422. PMID 5229984.

[pmid5696503-2] Steinrauf LK, Pinkerton M, Chamberlin JW (1968). "Nigeritsinning tuzilishi". Biokimyo. Biofiz. Res. Kommunal. 33 (1): 29–31. doi:10.1016 / 0006-291X (68) 90249-0. PMID 5696503.

[3] Mariathasan, S; Vayss, DS; Nyuton, K; McBride, J; O'Rourke, K; Ruz-Girma, M; Li, WP; Vaynrauch, Y; Monak, DM; Dixit, VM (2006 yil 9 mart). "Kriyopirin toksinlar va ATPga javoban yallig'lanishni faollashtiradi". Tabiat. 440 (7081): 228–32. Bibcode:2006 yil natur.440..228M. doi:10.1038 / tabiat04515. PMID 16407890.

[4] Muñoz-Planillo, R; Kuffa, P; Martines-Kolon, G; Smit, BL; Rajendiran, TM; Nunez, G (2013 yil 27-iyun). "K⁺ efflux - bu bakterial toksinlar va zarrachalar ta'sirida NLRP3 inflammasom faollashuvining umumiy qo'zg'atuvchisi". Immunitet. 38 (6): 1142–53. doi:10.1016 / j.immuni.2013.05.016. PMC 3730833. PMID 23809161.

[1]

[2]

[3]

[4]

Ismlar

IUPAC nomi (2R) -2 - [(2R, 3S, 6R) -6 - [[(2S, 4R, 5R, 7R, 9R, 10R) -2 - [(2R, 5S) -5 - [(2R, 3S, 5R) -5 - [(2S, 3S, 5R, 6R) -6-gidroksi-6- (gidroksimetil) -3,5-dimetil-2-tetrahidropiranil] -3-metil-2-tetrahidrofuranil] -5-metil- 2-tetrahidrofuranil] -9-metoksi-2,4,10-trimetil-1,6-dioksaspiro [4.5] dekan-7-yl] metil] -3-metil-2-tetrahidropiranil] propanoik kislota
Boshqa ismlar Polieterin A, Azalomitsin M, Helixin C, Helix C
Identifikatorlar
CAS raqami	28380-24-7^Y
3D model (JSmol )	Interaktiv rasm
ChEBI	CHEBI: 7569^Y
ChEMBL	ChEMBL405862^Y
ChemSpider	10196461^Y
ECHA ma'lumot kartasi	100.212.814
PubChem CID	34230
UNII	RRU6GY95IS^Y
CompTox boshqaruv paneli (EPA)	DTXSID9041079
InChI InChI = 1S / C40H68O11 / c1-21-11-12-28 (46-33 (21) 26 (6) 36 (42) 43) 17-29-18-30 (45-10) 27 (7) 40) 48-29) 25 (5) 19-38 (9,51-40) 32-13-14-37 (8,49-32) 35-23 (3) 16-31 (47-35) 34-22 ( 2) 15-24 (4) 39 (44,20-41) 50-34 / h21-35,41,44H, 11-20H2,1-10H3, (H, 42,43) / t21-, 22-, 23-, 24 +, 25 +, 26 +, 27 +, 28 +, 29 +, 30 +, 31 +, 32 +, 33 +, 34-, 35 +, 37-, 38-, 39-, 40 + / m0 / s1^Y Kalit: DANUORFCFTYTSZ-SJSJOXFOSA-N^Y InChI = 1 / C40H68O11 / c1-21-11-12-28 (46-33 (21) 26 (6) 36 (42) 43) 17-29-18-30 (45-10) 27 (7) 40) 48-29) 25 (5) 19-38 (9,51-40) 32-13-14-37 (8,49-32) 35-23 (3) 16-31 (47-35) 34-22 ( 2) 15-24 (4) 39 (44,20-41) 50-34 / h21-35,41,44H, 11-20H2,1-10H3, (H, 42,43) / t21-, 22-, 23-, 24 +, 25 +, 26 +, 27 +, 28 +, 29 +, 30 +, 31 +, 32 +, 33 +, 34-, 35 +, 37-, 38-, 39-, 40 + / m0 / s1 Kalit: DANUORFCFTYTSZ-SJSJOXFOBS
Jilmayganlar OC (= O) [C @ H] (C) [C @@ H] 1O [C @ H] (CC [C @@ H] 1C) C [C @ H] 6O [C @] 2 (O [ C @@] (C) (C [C @ H] 2C) [C @ H] 3CC [C @] (C) (O3) [C @@ H] 4O [C @ H] (C [C @@) H] 4C) [C @ H] 5O [C @@] (O) (CO) [C @ H] (C) C [C @@ H] 5C) [C @ H] (C) [C @ H ] (OC) C6
Xususiyatlari
Kimyoviy formulalar	C₄₀H₆₈O₁₁
Molyar massa	724,96132 g / mol
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar berilgan standart holat (25 ° C [77 ° F], 100 kPa da).
N tasdiqlang (nima bu ^YN ?)
Infobox ma'lumotnomalari