Relacorilant - Relacorilant - Wikipedia

Relacorilant

Klinik ma'lumotlar
Boshqa ismlar	CORT-125134
Marshrutlari ma'muriyat	Og'iz orqali
Giyohvand moddalar sinfi	Antiglyukokortikoid
Identifikatorlar
IUPAC nomi [(4aR) -1- (4-fluorophenyl) -6- (1-methylpyrazol-4-yl) sulfanyl-4,5,7,8-tetrahidropyrazolo [3,4-g] isoquinolin-4a-yl] - [4- ( triflorometil) piridin-2-il] metanon
CAS raqami	1496510-51-0
PubChem CID	73051463
ChemSpider	57617720
UNII	2158753C7E
KEGG	D11336
Kimyoviy va fizik ma'lumotlar
Formula	C27H22F4N6O3S
Molyar massa	586.57 g · mol−1
3D model (JSmol )	Interaktiv rasm
Jilmayganlar CN1C = C (C = N1) S (= O) (= O) N2CCC3 = CC4 = C (C [C @@] 3 (C2) C (= O) C5 = NC = CC (= C5) C (F) ) (F) F) C = NN4C6 = CC = C (C = C6) F
InChI InChI = 1S / C27H22F4N6O3S / c1-35-15-22 (14-33-35) 41 (39,40) 36-9-7-18-11-24-17 (13-34-37 (24) 21- 4-2-20 (28) 3-5-21) 12-26 (18,16-36) 25 (38) 23-10-19 (6-8-32-23) 27 (29,30) 31 / h2-6,8,10-11,13-15H, 7,9,12,16H2,1H3 / t26- / m0 / s1 Kalit: WANIDIGFXJFFEL-SANMLTNESA-N

Relacorilant (rivojlanish kodining nomi CORT-125134) an antiglyukokortikoid davolash uchun Corcept Therapeutics tomonidan ishlab chiqilgan Kushing sindromi.^[1] Shuningdek, davolash uchun ishlab chiqilmoqda qattiq o'smalar va alkogolizm.^[1][2] Preparat a steroid bo'lmagan birikma va vazifasini bajaradi antagonist ning glyukokortikoid retseptorlari.^[1] 2017 yil dekabr holatiga ko'ra II bosqich klinik sinovlar Cushing sindromi uchun va I bosqich / II qattiq klinik tekshiruvlar, alkogolizmning klinik bosqichi esa noma'lum.^[1]

Shuningdek qarang

• Tergov gormonal agentlari ro'yxati § Glyukokortikoidlar

Adabiyotlar

Tashqi havolalar

• Relacorilant - AdisInsight

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