Tioperamid - Thioperamide

Tioperamid
Klinik ma'lumotlar

ATC kodi	yo'q
Identifikatorlar
IUPAC nomi N-Sikloheksil-4- (1H-imidazol-4-il) piperidin-1-karbiotioamid
CAS raqami	106243-16-7^N
PubChem CID	3035905
IUPHAR / BPS	1267
ChemSpider	2300031^Y
UNII	II4319BWUI
ChEMBL	ChEMBL260374^Y
CompTox boshqaruv paneli (EPA)	DTXSID50147555
Kimyoviy va fizik ma'lumotlar
Formula	C₁₅H₂₄N₄S
Molyar massa	292.45 g · mol⁻¹
3D model (JSmol )	Interaktiv rasm
Jilmayganlar S = C (NC1CCCCC1) N3CCC (c2cnc [nH] 2) CC3
InChI InChI = 1S / C15H24N4S / c20-15 (18-13-4-2-1-3-5-13) 19-8-6-12 (7-9-19) 14-10-16-11-17- 14 / h10-13H, 1-9H2, (H, 16,17) (H, 18,20)^Y Kalit: QKDDJDBFONZGBW-UHFFFAOYSA-N^Y
^NY (bu nima?) (tasdiqlash)

Tioperamid a kuchli HRH₄ antagonist va tanlangan HRH₃ antagonist kesib o'tishga qodir qon-miya to'sig'i.^[1]Tomonidan ishlatilgan Jan-Charlz Shvarts H ga oid dastlabki tajribalarida₃ retseptorlari.^[2] Tioperamid gistamin antagonisti ekanligi aniqlandi autoreseptorlar, bu gistaminning chiqarilishini salbiy tartibga soladi va gistaminergik neyronlarning faolligini avtoretseptorlarni blokirovkalash orqali kuchaytiradi va bu gistaminning ko'proq chiqarilishiga olib keladi.

Uning H ga ta'siri₃ uyg'oqlikni targ'ib qilish va xotirani mustahkamlashni yaxshilaydi deb o'ylashadi.

Shuningdek qarang

H₃ retseptorlari antagonisti

Adabiyotlar

^ "Tioperamid". IUPHAR / BPS farmakologiya bo'yicha qo'llanma.
^ Shvarts QK (iyun 2011). "H3 gistamin retseptorlari: kashfiyotdan pitolisant bilan klinik sinovlarga qadar". Britaniya farmakologiya jurnali. 163 (4): 713–21. doi:10.1111 / j.1476-5381.2011.01286.x. PMC 3111674. PMID 21615387.

Gistamin retseptorlari modulyatorlar
H₁	Agonistlar: 2-piridiletilamin Betaxistin Gistamin HTMT L-Histidin UR-AK49 Antagonistlar: Birinchi avlod: 4-metildifenhidramin Alimemazin Antazolin Azatadin Bamipin Benzatropin (benztropin) Bepotastin Bromazin Bromfeniramin Buklizin Captodiame Karbinoksamin Xlortsiklizin Xloropiramin Xloroten Xlorfenamin Xlorfenoksamin Sininarizin Klemastin Klobenzepam Klocinizin Kloperastin Siklizin Siproheptadin Dacemazine Dekloksizin Deptropin Deksbromfeniramin Deksxlorfeniramin Dimenhidrinat Dimetindene Difengidramin Difenilpiralin Doksilamin Embramin Etodroksizin Etibenzatropin (etilbenztropin) Etimemazin Fenetazin Flunarizin Histapirrodin Gomoxlortsiklizin Gidroksietilprometazin Gidroksizin Izoprometazin Izotipendil Meklozin Medrilamin Mepiramin (pirilamin) Mequitazin Metafurilen Metapirilen Metdilazin Moksastin Orfenadrin Oksatomid Oksomemazin Perlapin Fenindamin Feniramin Feniltoloksamin Pimeteksen Piperoksan Pipoksizin Prometazin Propiomazin Pirrobutamin Talastin Tenalidin Tenildiamin Tiazinamium Tonzilamin Tolpropamin Tripelennamin Triprolidin Ikkinchi / uchinchi avlod: Akrivastin Alinastin Astemizol Azelastin Bamirastin Barmastin Bepiastin Bepotastin Bilastin Kabastinen Karbastin Cetirizine Klemastin Klemizol Klobenztropin Desloratadin Dorastin Ebastin Efletirizin Emedastin Epinastin Feksofenadin Flezelastin Ketotifen Latrepirdin Levokabastin Levotsetirizin Linetastin Loratadin Mapinastin Mebhidrolin Mizolastin Moksastin Noberastin Oktastin Olopatadin Perastin Pibaksizin Piklopastin Quifenadin (fenkarol) Rokastin Rupatadin Setastin Sekifenadin (bikarfen) Talastin Temelastin Terfenadin Vapitadin Zepastin Boshqalar: Atipik antipsikotiklar (masalan, aripiprazol, asenapin, brekspiprazol, brilaroksazin, klozapin, iloperidon, olanzapin, paliperidon, ketiapin, risperidon, ziprasidon, zotepin ) Fenilpiperazin antidepressantlar (masalan, gidroksifazodon, nefazodon, trazodon, triazoledion ) Tetratsiklik antidepressantlar (masalan, amoksapin, loxapin, maprotilin, mianserin, mirtazapin, oksaprotilin ) Trisiklik antidepressantlar (masalan, amitriptilin, butriptilin, klomipramin, desipramin, dozulepin (dotiepin), doksepin, imipramin, iprindol, lofepramin, nortriptilin, protriptilin, trimipramin ) Odatda antipsikotiklar (masalan, xlorpromazin, flupentiksol, flüfenazin, loxapin, perfenazin, proxlorperazin, tioridazin, tiyotiksen ) Noma'lum / saralanmagan: Azanator Belorizin Elbanizin Flotrenizin GSK1004723 Napaktadin Tagorizin Trelnarizin Trenizin
H₂	Agonistlar: Amtamin Betazol Dimaprit Gistamin HTMT Impromidin L-Histidin UR-AK49 Antagonistlar: Bisfentidin Burimamid Simetidin Dalkotidin Donetidin Ebrotidin Etintidin Famotidin Izolamtidin Lafutidin Lamtidin Lavoltidin (loxtidin) Lupitidin Metiamid Mifentidin Niperotidin Nizatidin Osutidin Oksmetidin Pibutidin Quisultazine (quisultidine) Ramixotidin Ranitidin Roksatidin Sufotidin Tiotidin Tuvatidin Venritidin Xaltidin Zolantidin
H₃	Agonistlar: a-metilhistamin Kipralizant Gistamin Imetit Immepip Immetridin L-Histidin Methimepip Proksifan Antagonistlar: A-349821 A-423579 ABT-239 ABT-652 AZD5213 Bavisant Betaxistin Burimamid Siproksifan Klobenpropit Konessin Quvnoq GSK-189254 Impentamin Iodofenpropit Irdabisant JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Tioperamid VUF-5681
H₄	Agonistlar: 4-metilhistamin a-metilhistamin Gistamin L-Histidin OUP-16 VUF-8430 Antagonistlar: JNJ-7777120 Mianserin Seliforant Tioperamid Toreforant VUF-6002
Shuningdek qarang: Retseptor / signalizatsiya modulyatorlari • Monoamin metabolizmining modulyatorlari • Monoaminni qaytarib olish inhibitörleri

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