Trifluperidol - Trifluperidol

Trifluperidol
Klinik ma'lumotlar
AHFS /Drugs.com	Giyohvand moddalarning xalqaro nomlari
Marshrutlari; ma'muriyat	Og'zaki
ATC kodi	N05AD02 (JSSV) ;
Identifikatorlar
	IUPAC nomi 1- (4-florofenil) -4- [4-gidroksi-4- [3- (triflorometil) fenil] piperidin-1-il] butan-1-on;
CAS raqami	749-13-3 ;
PubChem CID	5567;
ChemSpider	5366 ;
UNII	R8869Q7R8I;
ChEMBL	ChEMBL15023 ;
CompTox boshqaruv paneli (EPA)	DTXSID4023703 ;
Kimyoviy va fizik ma'lumotlar
Formula	C22H23F4NO2
Molyar massa	409.425 g · mol−1
3D model (JSmol )	Interaktiv rasm;
	Jilmayganlar FC (F) (F) c1cccc (c1) C3 (O) CCN (CCCC (= O) c2ccc (F) cc2) CC3;
	InChI InChI = 1S / C22H23F4NO2 / c23-19-8-6-16 (7-9-19) 20 (28) 5-2-12-27-13-10-21 (29,11-14-27) 17- 3-1-4-18 (15-17) 22 (24,25) 26 / h1,3-4,6-9,15,29H, 2,5,10-14H2 ; Kalit: GPMXUUPHFNMNDH-UHFFFAOYSA-N ;
	(bu nima?) (tasdiqlash)

Trifluperidol a odatda antipsikotik ning butirofenon kimyoviy sinf. U o'xshash umumiy xususiyatlarga ega haloperidol, ammo og'irligi jihatidan ancha kuchliroq va ayniqsa, nisbatan og'irroq yon ta'sirga olib keladi kech diskineziya va boshqalar ekstrapiramidal effektlar. U psixozlarni davolashda ishlatiladi, shu jumladan mani va shizofreniya. Bu topilgan Janssen Pharmaceuticalica 1959 yilda.^[1]^[2]

Sintez

Trifluperidol sintezi: P. Yanssen, J. Adriaan, GB 895309 (1962), AQSh Patenti 3 438 991 (1969).

^ Gallant DM, Bishop MP, Timmons E, Stil CA (sentyabr, 1963). "Trifluperidolni nazorat ostida baholash: yangi kuchli psixofarmakologik vosita". Hozirgi terapevtik tadqiqotlar, klinik va eksperimental. 5: 463–71. PMID 14065098.
^ Gallant DM, Bishop MP, Timmons E, Stil CA (Noyabr 1963). "Trifluperidol: butirofenon hosilasi". Amerika psixiatriya jurnali. 120 (5): 485–7. doi:10.1176 / ajp.120.5.485. PMID 14051242.

Bu dori ga tegishli maqola asab tizimi a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

Antipsikotiklar (N05A )
Odatda	Butirofenonlar: Benperidol Bromperidol Droperidol Haloperidol^# Moperon Pipamperon Spiperon Timiperone Trifluperidol Difenilbutilpiperidinlar: Fluspirilen Penfluridol Pimozid Fenotiyazinlar: Asetofenazin Butaperazin Karfenazin (karfenazin)^‡ Xlorpromazin Cyamemazine Diksirazin Flüfenazin Levomepromazin (metotrimeprazin) Mesoridazin Perazin Periciazin Perfenazin Piperatsetazin Pipotiazin Proxlorperazin Promazin Sulforidazin Tiyopropazat Tioproperazin Tioridazin Trifluoperazin Triflupromazin Tioksantenlar: Xlorprotixen Klopentiksol Flupentiksol Tiotiksen (tiyotiksen) Zuklopentiksol
Bahsli	Benzamidlar: Amisulprid Levosulpirid Nemonaprid Remoksiprid^‡ Sulpirid Sultoprid Tiaprid Veraliprid^‡ Butirofenonlar: Melperone Trisikliklar: Karpipramin Klokapramin Klorotepin Clotiapine Loksapin Mosapramin Boshqalar: Molindone
Atipik	Benzisoksazol /benzizotiyazollar: Iloperidon Lurasidon Paliperidon Paliperidon palmitati Perospiron Risperidon^# Ziprasidon Butirofenonlar: Lumateperon Fenilpiperazinlar /kinolinonlar: Aripiprazol Aripiprazol lauroksil Brilaroksazin^† Brexpiprazol Kariprazin Trisikliklar: Asenapin Klozapin^# Olanzapin Ketiapin Zotepin Boshqalar: Blonanserin Pimavanserin Sertindol
Boshqalar	Azatsiklonol Kannabidiol Oksipertin Reserpine Tetrabenazin
^#JSST-EM ^‡Olingan bozordan Klinik sinovlar: ^†III bosqich ^§Hech qachon III bosqichga

Klinik ma'lumotlar

AHFS /Drugs.com	Giyohvand moddalarning xalqaro nomlari
Marshrutlari ma'muriyat	Og'zaki
ATC kodi	N05AD02 (JSSV)
Identifikatorlar
IUPAC nomi 1- (4-florofenil) -4- [4-gidroksi-4- [3- (triflorometil) fenil] piperidin-1-il] butan-1-on
CAS raqami	749-13-3^N
PubChem CID	5567
ChemSpider	5366^Y
UNII	R8869Q7R8I
ChEMBL	ChEMBL15023^Y
CompTox boshqaruv paneli (EPA)	DTXSID4023703
Kimyoviy va fizik ma'lumotlar
Formula	C₂₂H₂₃F₄NO₂
Molyar massa	409.425 g · mol⁻¹
3D model (JSmol )	Interaktiv rasm
Jilmayganlar FC (F) (F) c1cccc (c1) C3 (O) CCN (CCCC (= O) c2ccc (F) cc2) CC3
InChI InChI = 1S / C22H23F4NO2 / c23-19-8-6-16 (7-9-19) 20 (28) 5-2-12-27-13-10-21 (29,11-14-27) 17- 3-1-4-18 (15-17) 22 (24,25) 26 / h1,3-4,6-9,15,29H, 2,5,10-14H2^Y Kalit: GPMXUUPHFNMNDH-UHFFFAOYSA-N^Y
^NY (bu nima?) (tasdiqlash)