Nepadutant - Nepadutant

Nepadutant
Klinik ma'lumotlar
Marshrutlari; ma'muriyat	Qarshi
ATC kodi	Yo'q;
Farmakokinetik ma'lumotlar
Bioavailability	<3% (og'zaki )
Yo'q qilish yarim hayot	44 daqiqa (IV )
Identifikatorlar
	IUPAC nomi (2S) -2 - [[(3S, 6S, 9S, 12S) -12 - [[(2S) -4 - [[(2R, 3R, 4R, 5S, 6R) -3-asetamido-4,5- dihidroksi-6- (gidroksimetil) oksan-2-il] amino] -2-amino-4-oksobutanoyl] amino] -6-benzil-9- (1H-indol-3-ilmetil) -5,8,11,14 -tetraokso-1,4,7,10-tetrazasiklotetradekan-3-karbonil] amino] -4-metilpentanoik kislota;
CAS raqami	183747-35-5;
PubChem CID	3086682;
IUPHAR / BPS	2123;
ChemSpider	2343247;
UNII	XW59TYL1XH;
Kimyoviy va fizik ma'lumotlar
Formula	C45H60N10O14
Molyar massa	965.031 g · mol−1
3D model (JSmol )	Interaktiv rasm;
	Jilmayganlar CC (C) C [C @@ H] (C (= O) O) NC (= O) [C @@ H] 1CNC (= O) C [C @@ H] (C (= O) N [ C @ H] (C (= O) N [C @ H] (C (= O) N1) Cc2ccccc2) Cc3c [nH] c4c3cccc4) NC (= O) [C @ H] (CC (= O) N [ C @ H] 5 [C @@ H] ([C @ H] ([C @@ H] ([C @ H] (O5) CO) O) O) NC (= O) C) N;
	InChI InChI = 1S / C45H60N10O14 / c1-21 (2) 13-31 (45 (67) 68) 53-43 (66) 32-19-48-34 (58) 17-30 (50-39 (62) 26) 46) 16-35 (59) 55-44-36 (49-22 (3) 57) 38 (61) 37 (60) 33 (20-56) 69-44) 42 (65) 52-29 (15-) 24-18-47-27-12-8-7-11-25 (24) 27) 41 (64) 51-28 (40 (63) 54-32) 14-23-9-5-4-6- 10-23 / h4-12,18,21,26,28-33,36-38,44,47,56,60-61H, 13-17,19-20,46H2,1-3H3, (H, 48 , 58) (H, 49,57) (H, 50,62) (H, 51,64) (H, 52,65) (H, 53,66) (H, 54,63) (H, 55,) 59) (H, 67,68) / t26-, 28-, 29-, 30-, 31-, 32-, 33 +, 36 +, 37 +, 38 +, 44 + / m0 / s1; Kalit: NPSVXOVMLVOMDD-SXRVEDALSA-N;

Nepadutant (KARVONSAROY ) (kod nomi MEN-11420) a glikozillangan velosiped siklo geksapeptid dori bu juda yuqori rol o'ynaydi tanlangan NK₂ retseptorlari antagonist.^[2]^[3]^[4] Bu tomonidan ishlab chiqilgan Menarini guruhi va davolash uchun tekshirildi funktsional oshqozon-ichak kasalliklari va Astma lekin hech qachon sotilmadi.^[3]^[5]^[6]

Shuningdek qarang

Adabiyotlar

^ ^a ^b ^v Tibbiy kimyo bo'yicha yillik hisobotlar. Akademik matbuot. 8 sentyabr 1999. 56-bet. ISBN 978-0-08-058378-5.
^ ^a ^b Piter Xolzer (2004 yil 17-iyun). Taxikininlar. Springer. 224-226 betlar. ISBN 978-3-540-20690-3.
^ ^a ^b Vera Regits-Zagrosek (2012 yil 2 oktyabr). Farmakologiyada jinsiy va jinsi farqlari. Springer Science & Business Media. 489– betlar. ISBN 978-3-642-30726-3.
^ Qirollik kimyo jamiyati (Buyuk Britaniya) (2003 yil yanvar). Aminokislotalar, peptidlar va oqsillar. Qirollik kimyo jamiyati. ISBN 978-0-85404-242-5.
^ Barbara Frank (2011 yil 29-iyun). Gastroenterologiyada ayollar muammolari, Gastroenterologiya klinikalarining muammolari. Elsevier sog'liqni saqlash fanlari. 54-55 betlar. ISBN 1-4557-1220-5.
^ Gabor Jancso (2008 yil 27-noyabr). Sog'liqni saqlash va kasallikdagi neyrogen yallig'lanish. Elsevier. 297– betlar. ISBN 978-0-444-53229-9.

Bu dori ga tegishli maqola asab tizimi a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[AcademicPress1999-1] v Tibbiy kimyo bo'yicha yillik hisobotlar. Akademik matbuot. 8 sentyabr 1999. 56-bet. ISBN 978-0-08-058378-5.

[Holzer2004-2] Piter Xolzer (2004 yil 17-iyun). Taxikininlar. Springer. 224-226 betlar. ISBN 978-3-540-20690-3.

[Regitz-Zagrosek2012-3] Vera Regits-Zagrosek (2012 yil 2 oktyabr). Farmakologiyada jinsiy va jinsi farqlari. Springer Science & Business Media. 489– betlar. ISBN 978-3-642-30726-3.

[Britain)2003-4] Qirollik kimyo jamiyati (Buyuk Britaniya) (2003 yil yanvar). Aminokislotalar, peptidlar va oqsillar. Qirollik kimyo jamiyati. ISBN 978-0-85404-242-5.

[Frank2011-5] Barbara Frank (2011 yil 29-iyun). Gastroenterologiyada ayollar muammolari, Gastroenterologiya klinikalarining muammolari. Elsevier sog'liqni saqlash fanlari. 54-55 betlar. ISBN 1-4557-1220-5.

[Jancso2008-6] Gabor Jancso (2008 yil 27-noyabr). Sog'liqni saqlash va kasallikdagi neyrogen yallig'lanish. Elsevier. 297– betlar. ISBN 978-0-444-53229-9.

[1]

[2]

[3]

[4]

[5]

[6]

Neyrokinin retseptorlari modulyatorlar
NK₁	Agonistlar: P moddasi Antagonistlar: Yaxshi Befetupitant Burapitant Kasopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743,310 L-758,298 Lanepitant LY-306740 Maropitant Netupitant NKP-608 Nolpitantium susayadi Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant
NK₂	Agonistlar: Neyrokinin A Antagonistlar: GR-159897 Ibodutant Nepadutant Saredutant
NK₃	Agonistlar: Neyrokinin B Senktayd Antagonistlar: Fezolinetant (ESN-364) Osanetant (SR-142,801) Pavinetant (MLE-4901, AZD-2624, AZD-4901) SB-218,795 SB-222,200 Taletant (SB-223,412)
Shuningdek qarang: Retseptorlari / signalizatsiya modulyatorlari • Signal peptid / oqsil retseptorlari modulyatorlari

Klinik ma'lumotlar

Marshrutlari ma'muriyat	Qarshi^[1]^[2]
ATC kodi	Yo'q
Farmakokinetik ma'lumotlar
Bioavailability	<3% (og'zaki )^[1]
Yo'q qilish yarim hayot	44 daqiqa (IV )^[1]
Identifikatorlar
IUPAC nomi (2S) -2 - [[(3S, 6S, 9S, 12S) -12 - [[(2S) -4 - [[(2R, 3R, 4R, 5S, 6R) -3-asetamido-4,5- dihidroksi-6- (gidroksimetil) oksan-2-il] amino] -2-amino-4-oksobutanoyl] amino] -6-benzil-9- (1H-indol-3-ilmetil) -5,8,11,14 -tetraokso-1,4,7,10-tetrazasiklotetradekan-3-karbonil] amino] -4-metilpentanoik kislota
CAS raqami	183747-35-5
PubChem CID	3086682
IUPHAR / BPS	2123
ChemSpider	2343247
UNII	XW59TYL1XH
Kimyoviy va fizik ma'lumotlar
Formula	C₄₅H₆₀N₁₀O₁₄
Molyar massa	965.031 g · mol⁻¹
3D model (JSmol )	Interaktiv rasm
Jilmayganlar CC (C) C [C @@ H] (C (= O) O) NC (= O) [C @@ H] 1CNC (= O) C [C @@ H] (C (= O) N [ C @ H] (C (= O) N [C @ H] (C (= O) N1) Cc2ccccc2) Cc3c [nH] c4c3cccc4) NC (= O) [C @ H] (CC (= O) N [ C @ H] 5 [C @@ H] ([C @ H] ([C @@ H] ([C @ H] (O5) CO) O) O) NC (= O) C) N
InChI InChI = 1S / C45H60N10O14 / c1-21 (2) 13-31 (45 (67) 68) 53-43 (66) 32-19-48-34 (58) 17-30 (50-39 (62) 26) 46) 16-35 (59) 55-44-36 (49-22 (3) 57) 38 (61) 37 (60) 33 (20-56) 69-44) 42 (65) 52-29 (15-) 24-18-47-27-12-8-7-11-25 (24) 27) 41 (64) 51-28 (40 (63) 54-32) 14-23-9-5-4-6- 10-23 / h4-12,18,21,26,28-33,36-38,44,47,56,60-61H, 13-17,19-20,46H2,1-3H3, (H, 48 , 58) (H, 49,57) (H, 50,62) (H, 51,64) (H, 52,65) (H, 53,66) (H, 54,63) (H, 55,) 59) (H, 67,68) / t26-, 28-, 29-, 30-, 31-, 32-, 33 +, 36 +, 37 +, 38 +, 44 + / m0 / s1 Kalit: NPSVXOVMLVOMDD-SXRVEDALSA-N