ZINC17988990 - ZINC17988990

ZINC17988990
Identifikatorlar
	IUPAC nomi (4-okso-5-fenil-3H-tieno [2,3-d] pirimidin-2-yl) metil 3- (3-okso-1,4-benzoksazin-4-yl) propanoat;
PubChem CID	27791261;
ChemSpider	22546450;
Kimyoviy va fizik ma'lumotlar
Formula	C24H19N3O5S
Molyar massa	461.49 g · mol−1
3D model (JSmol )	Interaktiv rasm;
	Jilmayganlar C1C (= O) N (C2 = CC = CC = C2O1) CCC (= O) OCC3 = NC4 = C (C (= CS4) C5 = CC = CC = C5) C (= O) N3;
	InChI InChI = 1S / C24H19N3O5S / c28-20-13-31-18-9-5-4-8-17 (18) 27 (20) 11-10-21 (29) 32-12-19-25-23 ( 30) 22-16 (14-33-24 (22) 26-19) 15-6-2-1-3-7-15 / h1-9,14H, 10-13H2, (H, 25,26,30) ); Kalit: YOFCRYWWKQMPEW-UHFFFAOYSA-N;

ZINC17988990 uchun kuchli va selektiv inhibitor vazifasini bajaradigan dori TRPV5 kaltsiy kanali, IC bilan₅₀ 177nM dan yuqori va TRPV5 uchun yuqori selektivlik TRPV6 va boshqa subtiplari TRPV. Bu TRPV5 uchun ishlab chiqilgan birinchi selektiv inhibitordir va buyraklardagi kaltsiy reabsorbtsiyasini modulyatsiya qilish uchun foydali bo'lishi mumkin.^[1]

Shuningdek qarang

Adabiyotlar

^ Xyuz TE, Del Rosario JS, Kapur A, Yazici AT, Yudin Y, Fluck EC va boshq. (Oktyabr 2019). "TRPV5 yangi inhibitörlerinin tuzilishga asoslangan tavsifi". eLife. 8. doi:10.7554 / eLife.49572. PMC 6834369. PMID 31647410.

Bu farmakologiya bilan bog'liq maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[pmid31647410-1] Xyuz TE, Del Rosario JS, Kapur A, Yazici AT, Yudin Y, Fluck EC va boshq. (Oktyabr 2019). "TRPV5 yangi inhibitörlerinin tuzilishga asoslangan tavsifi". eLife. 8. doi:10.7554 / eLife.49572. PMC 6834369. PMID 31647410.

[1]

Identifikatorlar

IUPAC nomi (4-okso-5-fenil-3H-tieno [2,3-d] pirimidin-2-yl) metil 3- (3-okso-1,4-benzoksazin-4-yl) propanoat
PubChem CID	27791261
ChemSpider	22546450
Kimyoviy va fizik ma'lumotlar
Formula	C₂₄H₁₉N₃O₅S
Molyar massa	461.49 g · mol⁻¹
3D model (JSmol )	Interaktiv rasm
Jilmayganlar C1C (= O) N (C2 = CC = CC = C2O1) CCC (= O) OCC3 = NC4 = C (C (= CS4) C5 = CC = CC = C5) C (= O) N3
InChI InChI = 1S / C24H19N3O5S / c28-20-13-31-18-9-5-4-8-17 (18) 27 (20) 11-10-21 (29) 32-12-19-25-23 ( 30) 22-16 (14-33-24 (22) 26-19) 15-6-2-1-3-7-15 / h1-9,14H, 10-13H2, (H, 25,26,30) ) Kalit: YOFCRYWWKQMPEW-UHFFFAOYSA-N